Patient demographics and lung function recorded when they were not taking β blockers in the 38 participants and split according to the presence or absence of chronic obstructive pulmonary disease
| Whole group (n=38) | Non-COPD (n=23) | COPD (n=15) | p Value | |
|---|---|---|---|---|
| Age (years) | 70 (5) | 69 (6) | 72 (4) | 0.16 |
| Male | 33 (87%) | 19 (83%) | 14 (93%) | 0.35 |
| Female | 5 (13%) | 4 (17%) | 1 (7%) | |
| BMI (kg/m2) | 29.1 (4.3) | 29.3 (4) | 28.6 (5) | 0.72 |
| Smoking | ||||
| Current | 10 (26%) | 5 (22%) | 5 (33%) | <0.01 |
| Ex-smoker | 19 (50%) | 9 (39%) | 10 (67%) | |
| Non-smoker | 9 (24%) | 9 (39%) | 0 | |
| Pack years | 31 (0–100) | 23(0–80) | 43.5 (12–100) | 0.02 |
| Current β blocker | ||||
| No | 22 (58%) | 10 (43%) | 12 (80%) | 0.83 |
| Yes | 16 (42%) | 13 (57%) | 3 (20%) | |
| FEV1 (L) | 2.57 (0.69) | 2.86 (0.61) | 2.03 (0.55) | <0.01 |
| FEV1 (%) | 94.8 (22.4) | 105.4 (17.9) | 75.0 (16.1) | <0.01 |
| FEV1/FVC | 0.69 (0.12) | 0.75 (0.05) | 0.56 (0.08) | <0.01 |
| FVC (L) | 3.68 (0.76) | 3.71 (0.8) | 3.61 (0.8) | 0.68 |
| FVC (%) | 107.3 (18.7) | 110 (19.9) | 103.0 (16.8) | 0.31 |
| RV/TLC | 46.2 (15) | 42.4 (16.7) | 52.5 (10.3) | <0.01 |
| TLCO (mmol/min/kPa) | 6.28 (1.84) | 6.44 (1.53) | 6.04 (2.28) | 0.52 |
| TLCO (% predicted) | 78.2 (20.1) | 80.4 (16.5) | 74.8 (24.9) | 0.52 |
| KCO (units/min) | 1.17 (0.28) | 1.24 (0.22) | 1.06 (0.33) | 0.41 |
| KCO (% predicted) | 91.3 (22.8) | 94.9 (20.1) | 85.7 (26.3) | 0.23 |
| Raw (kPa/s/L) | 2.31 (0.88) | 2.17 (0.74) | 2.63 (1.05) | 0.31 |
| sGaw (kPa/s) | 0.12 (0.05) | 0.14 (0.05) | 0.08 (0.03) | <0.01 |
| sRaw (kPa/s) | 9.23 (3.62) | 7.61 (3.12) | 11.71 (2.76) | <0.01 |
| Resting IC (L) | 2.91 (0.39) | 2.71 (0.48) | 2.99 (0.48) | 0.28 |
| Change in IC (L)—dynamic hyperinflation | −0.09 (0.25) | −0.02 (0.24) | −0.20 (0.23) | 0.02 |
Results are shown as mean±SD with the exception of pack years which is presented as mean (range).
FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; IC, inspiratory capacity; KCO, transfer coefficient for carbon monoxide; Raw, airway resistance; RV, residual volume; sGaw, specific airway conductance; sRaw, specific airway resistance; TLC, total lung capacity; TLCO, diffusing capacity for carbon monoxide.