Table 1

HRCT criteria for UIP-like fibrotic patterns in patients who meet the protocol criteria for PF-ILD*

The study will be enriched for patients meeting either criteria A, B and C, criteria A and C, or criteria B and C as described below. These patients will be referred to as ‘patients with HRCT with UIP-like fibrotic pattern only.’ Patients with PF-ILD who do not meet these criteria will be referred to as ‘patients with other HRCT fibrotic patterns.’
ADefinite honeycomb lung destruction with basal and peripheral predominance
BPresence of reticular abnormality and traction bronchiectasis consistent with fibrosis with basal and peripheral predominance
CAtypical features are absent, specifically nodules and consolidation.
Ground glass opacity, if present, is less extensive than reticular opacity pattern.
  • *Patients with fibrosing interstitial lung disease who meet diagnostic criteria for idiopathic pulmonary fibrosis, according to the American Thoracic Society/European Respiratory Society/Japanese Respiratory Society/Latin American Thoracic Association 2011 guidelines,13 will be excluded.

  • HRCT, high-resolution CT; PF-ILD, progressive fibrosing interstitial lung disease; UIP, usual interstitial pneumonia.