HRCT criteria for UIP-like fibrotic patterns in patients who meet the protocol criteria for PF-ILD*
| The study will be enriched for patients meeting either criteria A, B and C, criteria A and C, or criteria B and C as described below. These patients will be referred to as ‘patients with HRCT with UIP-like fibrotic pattern only.’ Patients with PF-ILD who do not meet these criteria will be referred to as ‘patients with other HRCT fibrotic patterns.’ | |
| A | Definite honeycomb lung destruction with basal and peripheral predominance |
| B | Presence of reticular abnormality and traction bronchiectasis consistent with fibrosis with basal and peripheral predominance |
| C | Atypical features are absent, specifically nodules and consolidation. Ground glass opacity, if present, is less extensive than reticular opacity pattern. |
*Patients with fibrosing interstitial lung disease who meet diagnostic criteria for idiopathic pulmonary fibrosis, according to the American Thoracic Society/European Respiratory Society/Japanese Respiratory Society/Latin American Thoracic Association 2011 guidelines,13 will be excluded.
HRCT, high-resolution CT; PF-ILD, progressive fibrosing interstitial lung disease; UIP, usual interstitial pneumonia.