Transplant considered* | Similarly hypoxaemic cohort† | p Value‡ | |
PAVM cases | 5 | 42 | - |
Age, median (Q1, Q3), year | 43 (34, 48) | 61 (37, 68) | 0.26 |
Male gender, no. (%) | 2 (40%) | 27 (40.5%) | 0.98 |
Multiple PAVMs, no. (%) | 5 (100%) | 28 (56%) | 0.12 |
SaO2, median (Q1, Q3), % | 82.5 (79, 84) | 82.9 (80, 84) | 0.86 |
Haemoglobin, median (Q1, Q3), g/L | 165 (139, 201) | 155.5 (132, 173) | 0.51 |
CaO2, median (Q1, Q3), mls O2/L | 182 (173, 232) | 173 (138, 190) | 0.18 |
Haematocrit, median (Q1, Q3) | 0.48 (0.41, 0.56) | 0.47 (0.44, 0.49) | 0.57 |
Serum iron (Q1, Q3), (μmol/L) | 15 (8, 25) | 15 (9, 24) | 0.91 |
TfSI (Q1, Q3),% | 26 (16, 41) | 22 (13, 36) | 0.75 |
Ferritin (Q1, Q3), μg/L | 56 (20, 124) | 57.5 (15.5, 140) | 0.91 |
C reactive protein (Q1, Q3), IU/mL | 3.5 (0.5, 4.8) | 2 (1.1, 8) | 0.86 |
Fibrinogen (Q1, Q3), g/L | 2.8 (2.4, 3.4) | 3.2 (2.75, 3.73) | 0.28 |
Albumin (Q1, Q3), g/L | 39 (36, 41) | 39 (37, 42) | 0.91 |
FEV1 (% predicted) | 74 (43, 99) | 90 (74, 100) | 0.40 |
FEV1/VC | 82 (76, 89) | 81 (74, 88) | 0.92 |
KCO (% predicted) | 76 (66, 95) | 82 (70, 94) | 0.77 |
PAP mean (Q1, Q3), mm Hg | 15.5 (8, 23) | 13 (12, 17) | 0.92 |
Cerebral abscess, no. (%) | 3 (60%) | 8 (19%) | 0.0043 |
Ischaemic stroke, no. (%) | 3 (60%) | 8 (19%) | 0.043 |
Venous thromboembolus, no. (%) | 3 (60%) | 3 (7.1%) | 0.0009 |
* The five cases considered for transplant have data entered at the most recent follow-up period (2016/2017 in three cases).
†The 42 cases (cohort B) are from the 445 described in reference,46 excluding one individual who had been previously considered for lung transplantation. Note that no individual could be in both cohorts. Both cohorts had normal renal function and white cell counts (data not shown).
‡p Values calculated by Mann-Whitney U test. Bold text indicates p Value <0.05
CaO2 , arterial oxygen content; FEV1, forced expiratory volume in 1 s; KCO, rate constant for carbon monoxide uptake from alveolar gas66; no, number; PAP, pulmonary artery pressure; PAVM, pulmonary arteriovenous malformation; SaO2, % of haemoglobin binding sites occupied by oxygen (oxygen saturation); TfSI, transferrin saturation index; VC, vital capacity; Q1, lower quartile; Q3 upper quartile.