Parameter | (A) Model 1, univariate | (B) Model 2, multivariate adjusted (as indicated in legend) | ||||
Exacerbation* history† | OR | 95% | p | OR‡ | 95% | p |
FEF25–75/FVC-ratio Quintile 1 versus 5 | 0.11 | 0.09 to 0.14 | <0.001 | 0.55 | 0.21 to 1.40 | 0.2 |
BMI Quintile 1 versus 5 | 1.28 | 1.10 to 1.50 | 0.002 | 1.08 | 0.65 to 1.79 | 0.7 |
Exacerbation* on follow up§ | OR | 95% | p | OR‡ | 95% | p |
FEF25–75/FVC ratio Quintile 1 versus 5 | 0.28 | 0.25 to 0.32 | <0.001 | 0.54 | 0.39 to 0.73 | <0.001 |
BMI Quintile 1 versus 5 | 1.1 | 0.97 to 1.25 | 0.14 | 1.13 | 0.892 to 1.39 | 0.2 |
Hospitalised** | OR | 95% | p | OR¶ | 95% | p |
FEF25–75/FVC ratio Quintile 1 versus 5 | 0.09 | 0.07 to 0.21 | <0.001 | 0.41 | 0.27 to 0.63 | <0.001 |
BMI Quintile 1 versus 5 | 0.97 | 0.79 to 1.19 | 0.8 | 1.30 | 0.94 to 1.79 | 0.1 |
Mortality†† | HR | 95% | p | HR¶ | 95% | p |
FEF25–75/FVC ratio Quintile 1 versus 5 | 0.17 | 0.13 to 0.23 | <0.001 | 0.60 | 0.39 to 0.94 | 0.02 |
BMI Quintile 1 versus 5 | 0.62 | 0.50 to 0.78 | <0.001 | 0.74 | 0.54 to 1.01 | 0.06 |
*Exacerbation analysis is stratified according to exacerbation yes/no.
†Exacerbation data from first study visit.
‡Adjusted for: BMI, age at enrolment, history of severe exacerbations, chronic bronchitis, asthma, American Thoracic Society (ATS) pack-year smoking, current smoking, fume exposure at work, gastro-oesophageal reflux disease, congestive heart failure, sleep apnoea, history of blood clots, high blood pressure, Modified Medical Research Council dyspnoea scale, St. George’s Respiratory Questionnaire score, forced expiratory volume in 1 s (%predicted) and 6 min walk distance.
§Exacerbation data from longitudinal follow-up data set.
¶Adjusted for: BMI, pack-year smoking, current smoking, oxygen use, per cent emphysema and Body mass index, airflow Obstruction, Dyspnoea and Exercise score.
**Hospitalisation analysis is stratified according to yes/no.
††Complete mortality data were available for 7534 subjects.
BMI, body mass index; FEF25–75, forced expiratory flow (25–75); FVC, forced vital capacity.