Response to treatment
| Control, n=57 | Endobronchial valves, n=44 | Between-group difference (95% CI) | t-test | |
| Δ FEV1 (mL) | 40 (17) | 185 (70) | 150 (60 to 230) | 0.0006 |
| Δ FEV1 (%) | 5.3 (14.7) | 23.1 (28.3) | 17.8 (26.5 to 9.2) | <0.0001 |
| Δ SGRQ symptoms | −5.9 (15.2) | −4.7 (22.8) | 1.2 (8.7 to 6.4) | 0.76 |
| Δ SGRQ activity | −0.3 (10.8) | −14.7 (20.9) | −14.4 (−8.0 to 20.7) | <0.0001 |
| Δ SGRQ impacts | −3.7 (13.2) | −14.2 (22.2) | −10.4 (−3.3 to 17.5) | 0.004 |
| Δ SGRQ total | −3.2 (9.8) | −12.7 (20.0) | −9.5 (−3.5 to 15.6) | 0.0022 |
| Δ TLC (L) | 0.02 (0.6) | −0.45 (0.47) | −0.47 (−0.22 to 0.73) | 0.0004 |
| Δ RV (L) | −0.06 (0.36) | −0.70 (0.52) | −0.64 (−0.425 to 0.863) | <0.0001 |
| Δ RV/TLC (%) | −0.7 (3.4) | −5.95 (7.3) | −5.2 (−3.0 to 7.4) | <0.0001 |
| Δ FRC (L) | 0.82 (0.48) | −0.53 (0.66) | −0.61 (−0.38 to 0.83) | <0.0001 |
| Δ Tlco(%predicted) | 0.02 (12.8) | 5.80 (14.6) | 5.7 (11.6 to 0.03) | 0.051 |
| Δ PaCO2 (kPa) | −0.01 (0.43) | −0.14 (0.59) | −0.13 (0.07 to 0.34) | 0.02 |
| Δ PaO2 (kPa) | 0.21 (0.97) | −0.29 (1.1) | −0.50 (0.07 to 0.93) | 0.03 |
| Δ 6MWD (m) | −5.6 (61.1) | 58.6 (87.2) | 64.2 (94.0 to 34.5) | <0.0001 |
6MWD, 6min walk distance; FEV1, forced expiratory volume in 1 s; FRC, functional residual capacity; PaCO2, arterial carbon dioxide tension; PaO2, arterial oxygen tension; RV, residual volume; SGRQ, St George’s Respiratory Questionnaire; Tlco, carbon monoxide transfer factor.