Table 1

Baseline characteristics

All n=114Control n=59Treatment n=55P value (t-test)
Age (years) 60.2 (8.6) 60.7 (8.1) 59.7 (9.1)0.5
Per cent female 55 66 440.016
BMI (kg/m2) 24.4 (4.2) 24.3 (4.1) 24.4 (4.3)0.90
mMRC  2.7 (0.6)  2.7 (0.56)  2.7 (0.70)0.74
Smoking (pack/years) 43.5 (23.3) 42.2 (22.6) 44.7 (24.1)0.56
SGRQ symptoms 59.4 (20.0) 61.2 (20.7) 57.5 (19.2)0.32
SGRQ activity 85.7 (10.9) 87.2 (9.8) 84.0 (11.8)0.12
SGRQ impacts 50.7 (17.3) 51.3 (17.2) 50.0 (17.7)0.68
SGRQ total 63.0 (13.5) 64.1 (13.2) 61.8 (13.9)0.36
FEV1 (L)  0.86 (.30)  0.82 (0.28)  0.90 (0.32)0.14
FEV1 %pred 30.6 (8.8) 30.5 (8.9) 30.6 (8.9)0.95
TLC %pred133.6 (13.2)137.0 (13.1)130.0 (12.5)0.004
RV %pred222.5 (37.9)230.5 (39.2)213.8 (34.8)0.018
RV/TLC 60.7 (8.4) 62.4 (8.1) 58.8 (8.5)0.026
FRC %pred188.5 (29.7)198.5 (29.3)176.5 (26.2)0.011
Tlco %pred 37.7 (9.8) 37.2 (9.8) 38.1 (9.8)0.65
PaCO2 kPa  9.4 (1.3)  5.0 (0.6)  5.0 (0.9)0.66
PaO2 kPa  9.4 (1.3)  9.3 (1.1)  9.4 (1.5)0.52
6 min walk distance (m)360 (87)359 (85)361 (89)0.89
BODE score  5.9 (1.3)  5.9 (1.2)  5.9 (1.4)0.87
  • BMI, body mass index; BODE, BMI, obstruction, dyspnoea, exercise capacity; FEV1, forced expiratory volume in 1 s; FRC, functional residual capacity; mMRC, modified Medical Research Council dyspnoea score; PaCO2, arterial carbon dioxide tension; PaO2, arterial oxygen tension; RV, residual volume; SGRQ, St George’s Respiratory Questionnaire; TLC, total lung capacity.