Number of exacerbations and severe exacerbations per year, change in FEV1, dyspnoea scores and distance covered in 6 min walk test from phase 1 to phase 2 visit (5-year interval)
| All (n=8479) | PREO-POSTO (n=3619) | PREN-POSTN (n=3936) | PREO-POSTN (n=636) | PREN-POSTO (n=288) | P value* | |
| Exacerbations per year±SD | 0.42±0.99 | 0.68±1.22 | 0.21±0.70 | 0.27±0.74 | 0.26±0.79 | 0.3 |
| Severe exacerbations per year±SD | 0.14±0.52 | 0.24±0.66 | 0.07±0.34 | 0.1±0.5 | 0.09±0.3 | 0.069 |