Associations of maternal genotypes and genotypic risk scores with haemoglobin concentrations in late pregnancy stratified by iron supplementation in late pregnancy
| SNPs | Risk allele* | Unsupplemented women (n=3055) | Supplemented women (n=2248) | ||
| β† (95% CI) | P trend | β† (95% CI) | P trend | ||
| rs1799945 | C | −0.12 (−0.19 to –0.06) | 1.3×10−4 | −0.04 (−0.12 to 0.04) | 0.31 |
| rs1800562 | G | −0.22 (−0.30 to –0.13) | 7.3×10−7 | −0.14 (−0.25 to –0.03) | 0.01 |
| rs855791 | A | −0.09 (−0.14 to –0.05) | 8.6×10−5 | −0.14 (−0.19 to –0.09) | 2.0×10−7 |
| rs8177240 | T/G‡ | −0.04 (−0.09 to 0.01) | 0.12 | −0.01 (−0.06 to 0.05) | 0.81 |
| rs7385804 | C | 0.00 (−0.05 to 0.05) | 0.95 | 0.00 (−0.05 to 0.06) | 0.86 |
| rs744653 | T | −0.04 (−0.11 to 0.02) | 0.18 | 0.06 (−0.02 to 0.13) | 0.14 |
| rs651007 | T | −0.05 (−0.11 to 0.01) | 0.08 | −0.04 (−0.10 to 0.03) | 0.27 |
| rs411988 | A | −0.02 (−0.06 to 0.03) | 0.46 | 0.02 (−0.04 to 0.07) | 0.54 |
| rs9990333 | C | 0.04 (0.00 to 0.09) | 0.07 | −0.05 (−0.10 to 0.00) | 0.06 |
| rs4921915 | A | −0.02 (−0.07 to 0.04) | 0.55 | 0.00 (−0.07 to 0.06) | 0.91 |
| rs6486121 | C | 0.00 (−0.04 to 0.05) | 0.86 | 0.02 (−0.03 to 0.08) | 0.40 |
| rs174577 | A | −0.01 (−0.05 to 0.04) | 0.76 | −0.02 (−0.08 to 0.03) | 0.41 |
| Iron score | −0.12 (−0.15 to –0.09) | 7.5×10−13 | −0.09 (−0.13 to –0.05) | 4.4×10−6 | |
| Ferritin score | −0.11 (−0.15 to –0.08) | 2.0×10−12 | −0.06 (−0.09 to –0.02) | 4.5×10−3 | |
| Transferrin score | −0.04 (−0.07 to –0.01) | 0.01 | −0.04 (−0.07 to 0.00) | 0.06 | |
| Transferrin saturation score | −0.11 (−0.14 to –0.07) | 8.1×10−11 | −0.08 (−0.12 to –0.04) | 2.8×10−5 | |
*Associated with lower iron status, lower ferritin status, higher transferrin status or lower transferrin saturation status with p<5.10−8.
†Per risk allele effect estimates are reported for SNPs, per SD increase effect estimates are reported for scores.
‡T is the risk allele for iron (associated with lower iron status) and G is the risk allele for transferrin and transferrin saturation (associated with higher transferrin status and lower transferrin saturation status).
SNP, single nucleotide polymorphism.