SNPs | Risk allele* | Nearest gene(s) | Effect estimates reported† | |||
Iron | Ferritin | Transferrin | Transferrin saturation | |||
rs1799945‡ | C | HFE | −0.189 | −0.065 | 0.114 | −0.231 |
rs1800562§ | G | HFE | −0.328 | −0.204 | 0.479 | −0.577 |
rs855791§ | A | TMPRSS6 | −0.181 | −0.055 | 0.044 | −0.190 |
rs8177240† | T/G¶ | TF | −0.066 | 0.380 | −0.100 | |
rs7385804‡ | C | TFR2 | −0.064 | −0.054 | ||
rs744653§ | T | WDR75–SLC40A1 | −0.089 | 0.068 | ||
rs651007‡ | T | ABO | −0.050 | |||
rs411988‡ | A | TEX14 | −0.044 | |||
rs9990333§ | C | TFRC | 0.051 | |||
rs4921915‡ | A | NAT2 | 0.079 | |||
rs6486121§ | C | ARNTL | 0.046 | |||
rs174577‡ | A | FADS2 | 0.062 |
*Associated with lower iron status, lower ferritin status, higher transferrin status or lower transferrin saturation status with p<5.10−8.
†From meta-analysis of covariate-adjusted standardised regression coefficients of phenotypic values on the allele count for the risk allele.
‡Imputed SNP.
§Genotyped SNP.
¶T is the risk allele for iron (associated with lower iron status) and G is the risk allele for transferrin and transferrin saturation (associated with higher transferrin status and lower transferrin saturation status).
SNP, single nucleotide polymorphism.