Associations between maternal genotypic scores and atopy, asthma, FEV1, FVC and FEF25-75 in the offspring of women without iron supplementation in late pregnancy
| OR or β*† (95% CI) | ||||
| Iron score | Ferritin score | Transferrin score | Transferrin saturation score | |
| Atopy (n=2208) | ||||
| Per SD increase | 1.08 (0.97 to 1.19) | 1.06 (0.95 to 1.17) | 0.97 (0.88 to 1.07) | 1.05 (0.95 to 1.17) |
| P for trend | 0.15 | 0.28 | 0.56 | 0.31 |
| Asthma (n=2787) | ||||
| Per SD increase | 1.09 (0.97 to 1.22) | 0.98 (0.88 to 1.10) | 1.00 (0.90 to 1.12) | 1.08 (0.96 to 1.21) |
| P for trend | 0.15 | 0.75 | 0.95 | 0.20 |
| FEV1 (n=2300) | ||||
| Per SD increase | −0.04 (−0.08 to 0.00) | −0.02 (−0.06 to 0.02) | −0.03 (−0.07 to 0.01) | −0.05 (−0.09 to −0.01) |
| P for trend | 0.07 | 0.38 | 0.13 | 0.03 |
| FVC (n=2336) | ||||
| Per SD increase | −0.03 (−0.07 to 0.01) | −0.01 (−0.05 to 0.03) | −0.03 (−0.07 to 0.01) | −0.04 (−0.08 to 0.00) |
| P for trend | 0.12 | 0.72 | 0.14 | 0.04 |
| FEF25-75 (n=2336) | ||||
| Per SD increase | −0.02 (−0.06 to 0.02) | −0.02 (−0.06 to 0.02) | −0.02 (−0.06 to 0.02) | −0.02 (−0.06 to 0.02) |
| P for trend | 0.35 | 0.39 | 0.36 | 0.28 |
*OR for asthma and atopy; difference in age, height and gender-adjusted SD units (β) for FEV1, FVC and FEF25-75.
†Adjusted for population substructure.
FEF25-75, maximal mid-expiratory flow; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.