Table 1

Stability of SGRQ total and domain scores in patients with stable disease

Change in FVC ≤2% predicted at week 6 (n=389)Change in UCSD-SOBQ score of <5 points at week 6 (n=351)Change in FVC ≤2% predicted at week 52 (n=187)Change in FVC ≤5% predicted at week 52 (n=419)Change in UCSD-SOBQ score of <5 points at week 52 (n=194)No change on PGI-C at week 52
(n=316)
ICCEffect sizeICCEffect sizeICCEffect sizeICCEffect sizeICCEffect sizeICCEffect size
SGRQ
 Total*0.83
(0.80–0.86)		−0.0290.91
(0.88–0.92)		−0.0470.75
(0.68–0.81)		0.0800.72
(0.67–0.77)		0.0470.87
(0.83–0.90)		−0.0030.76
(0.71–0.80)		0.181
 Activity domain0.81
(0.77–0.84)		0.0300.88
(0.85–0.90)		−0.0140.75
(0.68–0.81)		0.0770.71
(0.66–0.76)		0.0740.87
(0.83–0.90)		0.0480.73
(0.68–0.78)		0.220
 Impact domain0.76
(0.72–0.80)		−0.0350.87
(0.84–0.89)		−0.0780.67
(0.59–0.75)		0.0880.65
(0.58–0.70)		0.0680.80
(0.75–0.85)		−0.0110.68
(0.62–0.74)		0.166
 Symptoms domain0.72
(0.67–0.77)		−0.0600.76
(0.71–0.80)		0.0150.72
(0.64–0.78)		0.0330.66
(0.60–0.71)		−0.0710.68
(0.60–0.75)		−0.0380.66
(0.59–0.72)		0.067
UCSD-SOBQ score† 0.83
(0.80–0.86)		0.044N/AN/A0.75
(0.68–0.81)		0.1660.72
(0.66–0.76)		0.167N/AN/A0.75
(0.70–0.80)		0.235
CASA-Q
 Cough impacts domain0.74
(0.70–0.79)		0.0970.84
(0.81–0.87)		0.0430.67
(0.58–0.74)		0.0020.69
(0.63–0.74)		0.0160.76
(0.70–0.82)		0.0230.70
(0.64–0.75)		−0.099
 Cough symptoms domain0.70
(0.65–0.75)		0.0550.75
(0.70–0.79)		0.0580.60
(0.50–0.69)		−0.0150.61
(0.54–0.67)		0.0520.71
(0.64–0.77)		0.0770.66
(0.59–0.72)		−0.028
 EQ-5D VASN/CN/CN/CN/C0.60
(0.50–0.68)		−0.0300.49
(0.42–0.56)		−0.0740.68
(0.60–0.75)		−0.1240.51
(0.42–0.58)		−0.204

  • *n=315 patients with no change on PGI-C.

  • † n=410 for patients with FVC ≤5% predicted group and n=309 for patients with no change on PGI-C.

  • N/C: EQ-5D VAS data were not collected at week 6.

  • CASA-Q, Cough and Sputum Assessment Questionnaire; EQ-5D VAS, EuroQol 5-Dimensional Quality of Life Questionnaire Visual Analogue Scale; FVC, forced vital capacity; ICC, intraclass correlation coefficient; PGI-C, Patient ’s Global Impression of Change; SGRQ, St George’s Respiratory Questionnaire; UCSD-SOBQ, University of California San Diego Shortness of Breath Questionnaire.