Routine chemistry in the multipotent adultprogenitorcells groups for both routes of administration
| Haemodynamics and chemical variables | LPS/before cells | LPS/after cells | ||||
| Intravenou | EB | P value | Intravenous | EB | P value | |
| HR, bmp | 98.6±9.7 | 103.6±7.8 | 0.24 | 94.7±6.8 | 91.6±7 | 0.11 |
| MAP, mm Hg | 55.8±5.8 | 75.6±26.6 | 0.05 | 44±4.3 | 39±3.6 | 0.01 |
| Glucose | 60.2±16 | 65.6±8.3 | 0.59 | 20±6 | 36.6±12 | 0.32 |
| BUN, mg/dL | 12.5±0.5 | 14.6±2.7 | 0.45 | 13.9±0.05 | 19.6±2.3 | 0.13 |
| Creatinine, mg/dL | 0.85±0.15 | 0.6±0.03 | 0.5 | 1.1±0.2 | 1.8±0.06 | 0.14 |
| ALT, IU/L | <10 ± 0 | 17.3±0.8 | 0.12 | 15.6±1 | 16.5±0.5 | 0.04 |
| ALK P, IU/L | 92.6±28.5 | 178.6±68 | 0.42 | 126.5±45 | 257.6±82 | 0.26 |
| GGT, U/L | 29.5±0.5 | 33.6±2.3 | 0.54 | 36.5±0.5 | 36.3±3.1 | 0.96 |
Kidney and liver panels are within normal range. The EB group had a higher increase in MAP after infusion of LPS compared with the IT group. After the infusion of the cells both groups maintained similar values throughout the experiment. HR was initially high in both groups and was maintained stable during the entire experiment.
ALK, alkaline phosphatase; ALT, alanine aminotransferase; EB, endobronchial; GGT, gamma-glutamyl transferase; HR, heart rate; IT, Intratracheal; LPS, lipopolysaccharide; MAP, mean arterial pressure.