Pre-bronchodilator | Pre-bronchodilator | Post-bronchodilator | Post-bronchodilator | |||||
FEF50 (L/s) | FEF25–75% (L/s) | FEF50 (L/s) | FEF25–75% (L/s) | |||||
β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | |
All* | ||||||||
Smoking rate | n=320†‡ | n=320‡§ | n=272¶** | n=274**†† | ||||
Never-smoker | Reference | Reference | Reference | Reference | ||||
Regular smoker 1–14 cigarettes/day | −0.205 | −0.556 to 0.146 | −0.192 | −0.490 to 0.105 | −0.072 | −0.468 to 0.324 | 0.021 | −0.317 to 0.360 |
Regular smoker ≥15 cigarettes/day | −0.767 | −1.133 to − 0.401 | −0.586 | −0.895 to − 0.277 | −1.083 | −1.500 to − 0.666 | −0.871 | −1.227 to − 0.516 |
Per 10 cigarettes/day | −0.344 | −0.511 to − 0.177 | −0.278 | −0.419 to − 0.136 | −0.459 | −0.653 to − 0.265 | −0.364 | −0.531 to − 0.198 |
Cumulative smoking | n=318†‡‡ | n=318§‡‡ | n=270**§§ | n=272††§§ | ||||
Regular smoker 1–199 cigarette-years | −0.275 | −0.697 to 0.147 | −0.113 | −0.468 to 0.242 | −0.095 | −0.577 to 0.387 | 0.070 | −0.341 to 0.481 |
Regular smoker ≥200 cigarette-years | −0.610 | −0.948 to − 0.273 | −0.557 | −0.841 to − 0.274 | −0.835 | −1.225 to − 0.446 | −0.695 | −1.025 to − 0.364 |
Per 100 cigarette-years | −0.118 | −0.175 to − 0.061 | −0.097 | −0.145 to − 0.049 | −0.177 | −0.241 to − 0.113 | −0.142 | −0.197 to − 0.087 |
Men¶¶ | ||||||||
Smoking rate | n=95† | n=96§ | n=81¶ | n=83†† | ||||
Never-smoker | Reference | Reference | Reference | Reference | ||||
Regular smoker 1–14 cigarettes/day | 0.254 | −0.510 to 1.019 | −0.009 | −0.638 to 0.655 | 0.761 | −0.235 to 1.757 | 0.679 | −0.153 to 1.511 |
Regular smoker ≥15 cigarettes/day | −0.509 | −1.174 to 0.156 | −0.390 | −0.965 to 0.186 | −0.958 | −1.815 to − 0.101 | −0.738 | −1.471 to − 0.004 |
Per 10 cigarettes/day | −0.142 | −0.439 to 0.155 | −0.134 | −0.386 to 0.118 | −0.314 | −0.717 to 0.088 | −0.243 | −0.582 to 0.097 |
Cumulative smoking | n=95† | n=96§ | n=81¶ | n=83†† | ||||
Regular smoker 1–199 cigarette-years | 0.143 | −0.766 to 1.051 | 0.206 | −0.541 to 0.953 | 0.502 | −0.732 to 1.736 | 0.594 | −0.414 to 1.601 |
Regular smoker ≥200 cigarette-years | −0.354 | −1.010 to 0.302 | −0.427 | −0.984 to 0.130 | −0.611 | −1.487 to 0.246 | −0.498 | −1.239 to 0.242 |
Per 100 cigarette-years | −0.049 | −0.145 to 0.046 | −0.044 | −0.125 to 0.036 | −0.138 | −0.266 to − 0.010 | −0.111 | −0.218 to − 0.004 |
Women¶¶ | ||||||||
Smoking rate | n=225†‡ | n=224‡§ | n=191¶** | n=191**†† | ||||
Never-smoker | Reference | Reference | Reference | Reference | ||||
Regular smoker 1–14 cigarettes/day | −0.426 | −0.826 to − 0.027 | −0.317 | −0.654 to 0.019 | −0.423 | −0.835 to − 0.012 | −0.279 | −0.633 to 0.076 |
Regular smoker ≥15 cigarettes/day | −0.653 | −1.140 to − 0.166 | −0.504 | −0.911 to − 0.097 | −0.936 | −1.451 to − 0.422 | −0.763 | −1.202 to − 0.323 |
Per 10 cigarettes/day | −0.395 | −0.623 to − 0.166 | −0.304 | −0.496 to − 0.113 | −0.518 | −0.761 to − 0.274 | −0.405 | −0.614 to − 0.196 |
Cumulative smoking | n=223†‡‡ | n=222§‡‡ | n=189¶§§ | n=189**§§ | ||||
Regular smoker 1–199 cigarette-years | −0.465 | −0.937 to 0.008 | −0.276 | −0.676 to 0.123 | −0.344 | −0.832 to 0.145 | −0.173 | −0.596 to 0.250 |
Regular smoker ≥200 cigarette-years | −0.592 | −1.009 to − 0.175 | −0.514 | −0.861 to − 0.166 | −0.861 | −1.300 to − 0.421 | −0.714 | −1.088 to − 0.339 |
Per 100 cigarette-years | −0.152 | −0.240 to − 0.063 | −0.126 | −0.200 to − 0.053 | −0.208 | −0.299 to − 0.118 | −0.169 | −0.246 to − 0.091 |
*Adjusted for age, height, education, past 12 months secondhand smoking (SHS), lifetime cumulative SHS and mould odour.
†Pre-bronchodilator FEF50 is available for 322 regularly smoking or never-smoking participants (95 men and 227 women).
‡Smoking rate is missing for 2 women for daily smoking.
§Pre-bronchodilator FEF25–75% is available for 322 regularly smoking or never-smoking participants (96 men and 226 women).
¶Post-bronchodilator FEF50 is available for 273 regularly smoking or never-smoking participants (81 men and 192 women).
**Smoking rate is missing for 1 woman for daily smoking.
††Post-bronchodilator FEF25–75% is available for 275 regularly smoking or never-smoking participants (83 men and 192 women).
‡‡Cigarette-years is missing for 4 women.
§§Cigarette-years is missing for 3 women.
¶¶Adjusted for sex, age, height, education, past 12 months SHS, lifetime cumulative SHS and mould odour.