Conditional and marginal joint effects of treatment and weight status on time-to-management failure
| Treatment | Weight status | Events/Visit-weeks (n) | Average HR (95% CI)* | |
| Conditional | Marginal | |||
| LTRA monotherapy | BMI >80th percentile | 12/563 | 1.09 (0.60 to 2.00) | 1.14 (0.61 to 2.13) |
| BMI ≤80th percentile | 16/470 | 1.69 (1.00 to 2.88) | 1.72 (1.01 to 2.93) | |
| Overall | 28/1033 | |||
| Low-dose ICS monotherapy | BMI >80th percentile | 59/2184 | 1.18 (0.83 to 1.69) | 1.21 (0.84 to 1.74) |
| BMI ≤80th percentile | 61/2771 | 0.92 (0.60 to 1.43) | 0.96 (0.62 to 1.48) | |
| Overall | 120/4955 | |||
| Treatment non-compliance | BMI >80th percentile | 95/3531 | 1.40 (1.03 to 1.92) | 1.38 (1.00 to 1.89) |
| BMI ≤80th percentile† | 96/5010 | 1.00 (reference) | 1.00 (reference) | |
| Overall | 191/8541 | |||
*After accounting for age, sex, ethnicity, income, user type, global assessment of severity score, number of exacerbations in previous year, exposure to smoke, asthma-related comorbidities, triggers, % predicted FEV1, ICS rescue use and season.
†Reference category.
BMI, body mass index; FEV1, forced expiratory volume in 1 s; ICS, inhaled corticosteroids; LTRA, leukotriene receptor antagonist.