Topic | GRADE recommendation | Conditions |
Tidal volume | Strongly in favour | Tidal volume <6 mL/kg ideal body weight; Plateau pressure < 30 cmH2O |
Prone positioning | Strongly in favour | Proning for >12 hours per day Patients with moderate/severe ARDS (P:F ratio < 20 kPa) |
HFOV | Strongly against | |
Conservative fluid management | Weakly in favour | |
Higher PEEP | Weakly in favour | Patients with moderate or severe ARDS (PF ratio <27 kPa) |
NMBA | Weakly in favour | Evidence only for cisatracurium besylate Continuous 48 hours infusion Patients with moderate/severe ARDS (<20 kPa) |
ECMO | Weakly in favour | With lung-protective mechanical ventilation Patients with severe ARDS, lung injury score >3 or pH <7.20 due to uncompensated hypercapnoea |
Inhaled vasodilators | Weakly against | Evidence only for inhaled nitric oxide |
Corticosteroids | Research recommendation | |
ECCO2R | Research recommendation |
ARDS, acute respiratory distress syndrome; ECCO2R, extracorporeal carbon dioxide removal; ECMO, extracorporeal membrane oxygenation; FICM, Faculty of Intensive Care Medicine; HFOV, high frequency oscillation; ICS, Intensive Care Society; NMBA, neuromuscular blocking agents; PEEP, peek end-expiratory pressure.