HFOV compared to usual care for ARDS
| Patient or population: adults with ARDS Settings: intensive care Intervention: HFOV Comparison: standard care | ||||||
| Outcomes | Illustrative comparative risks (95% CI) | Relative effect (95% CI) | No. of participants (studies) | Quality of evidence (GRADE) | Comments | |
| Control risk | Intervention risk | |||||
| Standard care | HFOV | |||||
| Mortality (ICU) | 308 per 1000 | 442 per 1000 (308 to 447) | RR 1.22 (0.93 to 1.60) | 1321 (three studies) | +++- MODERATE Due to moderate inconsistency and mild indirectness | Changes in conventional ventilation strategies accounted for heterogeneity |
| Mortality (30 day) | 436 per 1000 | 453 per 1000 (362 to 571) | RR 1.04 (0.83 to 1.31) | 1580 (five studies) | +++- MODERATE Due to moderate inconsistency and mild indirectness | Changes in conventional ventilation strategies accounted for heterogeneity |
| Adverse events: barotrauma | 122 per 1000 | 147 per 1000 (101 to 212) | RR 1.205 (0.834 to 1.742) | 752 (four studies) | ++-- LOW Due to serious imprecision | Barotrauma variably defined |
| Adverse events: oxygen failure | 102 per 1000 | 77 per 1000 (61 to 89) | RR 0.557 (0.351 to 0.884) | 757 (three studies) | ++-- LOW Due to serious imprecision | Oxygenation failure variably defined. |
ARDS, acute respiratory distress syndrome; HFOV, high-frequency oscillatory ventilation.