Ability of severity assessment tools to risk stratify for outcome measures in CAP
| Outcome | CURB65 | P value | |||||
| 0 n=173 | 1 n=287 | 2 n=395 | 3 n=309 | 4 n=129 | 5 n=18 | ||
| 30-day mortality n (%) | 6 (3.5) | 33 (11.5) | 73 18.5) | 83 (26.9) | 58 (45.0) | 7 (38.9) | <0.001 |
| 90-day mortality n (%) | 10 (5.8) | 45 (15.7) | 103 (26.1) | 108 (35.0) | 65 (50.4) | 7 (38.9) | <0.001 |
| 365-day mortality n (%) | 11 (6.4) | 69 (24.0) | 132 (33.4) | 143 (46.3) | 73 (56.6) | 7 (38.9) | <0.001 |
| In-hospital death n (%) | 3 (1.7) | 25 (8.7) | 60 (15.2) | 67 (21.7) | 48 (37.2) | 5 (27.8) | <0.001 |
| ICU admission n (%) | 12 (6.9) | 15 (5.2) | 39 (9.9) | 13 (4.2) | 6 (4.7) | 2 (11.1) | 0.514 |
| Length of inpatient stay median days (IQR) | 3 (1.0–7.0) | 6 (3.0–13.0) | 8 (4.0–15.0) | 9 (5.0–17.0) | 8 (4.5–13.5) | 9 (4.5–14.0) | <0.001 |
| Lac-CURB-65 | |||||||
| Low n=204 | Moderate n=506 | High n=503 | |||||
| 30-day mortality n (%) | 9 (4.4) | 77 (15.2) | 166 (33.0) | <0.001 | |||
| 90-day mortality n (%) | 15 (7.4) | 107 (26.8) | 199 (39.6) | <0.001 | |||
| 365-day mortality n (%) | 29 (14.2) | 143 (28.3) | 243 (48.3) | <0.001 | |||
| In-hospital death n (%) | 5 (2.5) | 62 (12.3) | 134 (26.6) | <0.001 | |||
| ICU admission n (%) | 10 (4.9) | 41 (8.1) | 36 (7.1) | 0.483 | |||
| Length of inpatient stay median days (IQR) | 6 (2.0–10.0) | 7 (4.0–13.0) | 8 (5.0–16.0) | <0.001 | |||
| NEWS | |||||||
| Low n=557 | Moderate n=417 | High n=560 | |||||
| 30-day mortality n (%) | 61 (11.0) | 61 (14.6) | 168 (30.0) | <0.001 | |||
| 90-day mortality n (%) | 96 (17.2) | 93 (22.3) | 197 (35.2) | <0.001 | |||
| 365-day mortality n (%) | 137 (24.6) | 125 (30.0) | 243 (43.4) | <0.001 | |||
| In-hospital death n (%) | 56 (10.1) | 52 (12.5) | 127 (22.7) | <0.001 | |||
| ICU admission n (%) | 12 (2.1) | 25 (6.0) | 58 (10.4) | <0.001 | |||
| Length of inpatient stay median days (IQR) | 6 (3.0–12.0) | 7 (4.0–16.0) | 8 (4.0–14.8) | <0.001 | |||
| qSOFA score | |||||||
| 0 n=369 | 1 n=629 | 2 n=265 | 3 n=52 | ||||
| 30-day mortality n (%) | 43 (11.7) | 114 (18.4) | 82 (30.9) | 24 (46.2) | <0.001 | ||
| 90-day mortality n (%) | 62 (16.8) | 154 (24.5) | 100 (37.7) | 25 (48.1) | <0.001 | ||
| 365-day mortality n (%) | 86 (23.3) | 205 (32.6) | 119 (44.9) | 28 (53.8) | <0.001 | ||
| In-hospital death n (%) | 36 (9.8) | 86 (13.7) | 68 (25.7) | 20 (38.5) | <0.001 | ||
| ICU admission n (%) | 13 (3.5) | 49 (7.8) | 22 (8.3) | 3 (5.8) | 0.038 | ||
| Length of inpatient stay median days (IQR) | 6 (3.0–11.0) | 7 (4.0–15.0) | 8 (4.0–15.0) | 8 (5.0–15.75) | <0.001 | ||
Comparison of proportions done using χ2 test for trend. Trends in median length of stay assessed using the Jonckheere-Terpstra test.
Lac-CURB-65 cut-offs: low—CURB-65 ≤1 and/or lactate <2.0 mmol/L; moderate—CURB65=2 and/or lactate 2.0–4.0 mmol/L; high—CURB65 ≥3 and/or lactate >4.0 mmol/L. NEWS score cut-offs: low—aggregate score 1–4; medium—aggregate score 5–6 or a score of ≥3 in a single category; high—aggregate score ≥7 as previously defined.13 16
CAP, community-acquired pneumonia; ICU, intensive care unit; NEWS, National Early Warning Score; qSOFA, quick Sequential (Sepsis-related) Organ Failure Assessment.