Table 2

Primary and secondary study endpoints

Primary

  1. Agreement between TBLC and VATS histopathological diagnoses.

  2. Agreement between TBLC and VATS consensus MDD diagnoses.

Secondary

  1. Interobserver variability between individual pathologists in leading and differential diagnoses and degree of confidence.

  2. Interobserver variability between MDD participant diagnoses and degree of diagnostic confidence after:

    • Discussion of clinical and radiological details.

    • Addition of either TBLC or VATS biopsy findings.

  3. Comparison of consensus diagnosis and degree of diagnostic confidence following:

    • Discussion of clinical and radiological details.

    • Addition of either TBLC or VATS biopsy findings.

  4. Identification of patient clinical and histopathological features associated with agreement between diagnostic methods.

  • MDD, multidisciplinary discussion; TBLC, transbronchial lung cryobiopsy; VATS, video-assisted thoracoscopic surgery.