Table 2

Results of statistically and clinically significant univariable and multivariable analysis for repeat antibiotic prescription for LRTI code within 14 days of index duration. Univariable analysis according to type of data

Variable	Univariable analysis results			Multiple logistic regression model results
Variable	OR 95 % CI	Mean difference 95% CI	P value	OR 95 % CI	P value
Age		−0.66 −1.4 to 0.1	0.10
Location			<0.01
Midlands and East	Index
London	0.59 0.21 to 1.62		0.30
North	0.74 0.60 to 0.91		<0.01
South	0.77 0.64 to 0.93		0.01
Gastro-oesophageal reflux disease diagnosis	1.53 1.03 to 2.27		0.03
Cardiovascular disease diagnosis	1.63 1.34 to 1.95		<0.01	1.37 1.13 to 1.66	<0.01
Paracetamol prescription*	1.18 1.02 to 1.37		0.03
Pneumococcal vaccination	1.38 1.19 to 1.60		<0.01	1.33 1.14 to 1.55	<0.01
Number of primary care respiratory consultations*		−1.05 −1.29 to 0.82	<0.01	1.05 1.02 to 1.07	<0.01
Number of all primary care consultations*		−3.16 −3.89 to −2.43	<0.01	1.01 1.01 to 1.02	<0.01
Number of OCS*		−0.10 −0.20 to 0.00	0.05
Number of exacerbations*		−0.10 −0.20 to −0.01	0.06
FEV1 value (L)		0.02 −0.03 to 0.07	0.38
Count of ICS inhalers*		−0.41 −0.87 to 0.05	0.08
Count of LAMA prescriptions*		−0.33 −0.67 to 0.01	0.06
Count of LABA inhalers*		−0.20 −0.36 to −0.04	0.02	1.03 1.00 to 1.05	0.08
Count of LTRA prescriptions*		0.04 −0.16 to 0.00	0.06
Not amoxicillin as index antibiotic	1.37 1.18 to 1.58		<0.01	1.28 1.10 to 1.49	<0.01

Blank entries relate to variables not included in the multivariable model.
*In year prior to index prescription.
FEV1, forced expiratory volume in 1 s; ICS, inhaled corticosteroid; LABA, long-acting beta-agonist; LAMA, long-acting muscarinic antagonist; LRTI, lower respiratory tract infection; LTRA, Leukotriene receptor antagonist;OCS, oral corticosteroid.