Table 3

Univariate and multivariate Cox regression models for the prediction of 33-day mortality

Variable	Univariate HR (95% CI)	P value	Multivariate HR (95% CI)	P value
Time-varying RSI	1.06 (1.04 to1.08)	<0.0001	1.07 (1.05 to1.09)	<0.0001
Age	1.0 (1.0 to 1.1)	0.10
Gender
Female	1.0
Male	0.9 (0.5 to 2.0)	0.86
Race
White	1.0
Non-white	1.5 (0.7 to 3.2)	0.28
Underlying malignancy		0.12†
AML	1.0
MDS	0.6 (0.1 to 4.4)	0.61
ALL	3.3 (1.0 to 11.1)	0.05
Intensive chemotherapy
No	1.0
Yes	0.8 (0.4 to 1.6)	0.51
Baseline ECOG		0.17†
0	1.0
1	1.2 (0.3 to 4.1)	0.78
2	2.0 (0.5 to 7.3)	0.31
3/4	2.4 (0.4 to 14.4)	0.34
Pneumonia at induction
No	1.0
Yes	0.7 (0.2 to 1.9)	0.47
Baseline haemoglobin	0.8 (0.7 to 1.0)	0.06
Baseline platelet count	1.0 (0.99 to 1.01)	0.79
Baseline ANC	1.0 (0.99 to 1.09)	0.14
Time-varying ANC	1.0 (0.95 to 1.06)	0.99
Baseline bilirubin	1.6 (1.2 to2.2)	0.004	1.7 (1.2 to2.3)	0.001
Baseline creatinine	0.8 (0.4 to 1.7)	0.59
Blood culture*		0.25†
Negative	1.0
Positive	2.1 (0.9 to 4.8)	0.09
Sputum culture		0.02†		0.02
Negative	1.0		1.0
Positive	1.7 (0.7 to 4.3)	0.26	1.9 (0.7 to 4.9)	0.22
Not done	0.5 (0.2 to 1.3)	0.15	0.5 (0.2 to 1.3)	0.15
BAL culture		0.06
Negative	1.0
Positive	1.5 (0.6 to 4.2)	0.41
Not done	0.5 (0.2 to 1.2)	0.12
Bronchoscopy performed	2.2 (1.1 to4.6)	0.03

Statistically signiciant results are reported in bold.
*Three patients did not have a blood culture performed.
†Global p value.
ALL, acute lymphoblastic leukaemia; AML, acute myeloid leukaemia; ANC, absolute neutrophil count; BAL, bronchoalveolar lavage; ECOG, Eastern Cooperative Oncology Group; MDS, myelodysplastic syndrome; RSI, Radiologic Severity Index.