Table 6

Effect of any viral ARI during infancy on IPFT indices at 3 years of age

IPFTIPFT indicesUnitChildren with any viral ARI during infancy (n=154), median (IQR)Children without ARI during infancy (n=52), median (IQR)P-value
TBFVLVT/kgmL/kg11.3 (9.7–13.6)11.6 (10.2–13.8)0.8
TEF10mL/s123 (99–151)107 (82–139)0.02
TEF25mL/s155 (126–186)135 (11–173)0.02
MTEFmL/s131 (108–158)120 (98–138)0.04
TEF25/PTEF%79.7 (72.1–85.8)76.1 (68.4–83.4)0.03
TEF50/PTEF%89.6 (86–93)87.3 (89.2)0.02
RTCmax,FRCmL/s60 (0–105)50 (0–95)0.7
RVRTCFEV0.5mL58.2 (41–79.8)68 (45.3–101.8)0.03
FEV0.75mL79.5 (55.6–105.8)89.9 (69.6–125.1)0.03
FEV1.0mL98.6 (73.4–124.8)112.2 (77.3–139.7)0.04
FEVmL119.8 (85.6–144.3)137.1 (117.9–164.5)0.006
FEF25–75mL/s154.7 (102.3–212.1)212.5 (123.2–301.9)0.01
MEF25mL/s125 (90–180)177.5 (100–310)0.008
MEF10mL/s80 (60–130)130 (70–260)0.004
  • FEF25-75, forced expiratory flow between 25% and 75% of FVC; FEV0.5/0.75/1.0, forced expiratory volume in 0.5/0.75/1 sec; FEV, forced expiratory volume; IPFT, infants pulmonary function test; MEF25/MEF10, maximum expiratory flow at 25% or 10% of FVC; MTEF, mid tidal expiratory flow; RTC, rapid thoracoabdominal compression; RVRTC, raised volume rapid thoracoabdominal compression; TBFVL, tidal breathing flow-volume loop; TEF25 or TEF10, tidal expiratory flow when 25 % or 10 % of VT remaining for expiration; TEF25 or TEF50/PTEF, ratio of TEF25 or TEF50 to peaked tidal expiratory flow; Vʹmax,FRC, maximal flow at FRC; VT, tidal volume.