Table 5

Effect of ARI during infancy on IPFT indices at 3 years of age (n=225)

IPFTIPFT indicesUnitChildren with ARI episode(s) during infancy (n=173), median (IQR)Children without documented ARI episode during infancy (n=52), median (IQR)P-value
TBFVLVT/kgmL/kg11.3 (9.7–13.5)11.6 (10.2–13.8)0.7
MTEFmL/s130 (107–157)120 (98–138)0.05
tPTEF/tE%39.6 (30.5–50.1)37.7 (29.6–46.8)0.19
TEF25mL/s153 (124–185)135 (110–173)0.02
TEF10mL/s121 (97–148)107 (82–139)0.04
TEF25/PTEF%79.7 (72.1–85.9)76.1 (68.6–83.8)0.04
TEF50/PTEF%89.8 (86.1–93.1)87.3 (85.5–89.2)0.002
RTCmax,FRCmL/s57.5 (0–105)50 (0–95)0.8
RVRTCFEV 0.5mL58.2 (41.6–81.6)68 (45.3–101.8)0.04
FEV 0.75mL79.4 (58.1–106.9)89.9 (69.6–125.1)0.02
FEV1.0mL96.8 (74.4–124.8)112.5 (77.3–139.7)0.04
FEVml119.4 (85.6–144.3)137 (117.9–164.5)0.004
MEF25mL/s125 (90–185)177.5 (100–310)0.01
MEF10mL/s80 (60–135)130 (70–260)0.003
FEF25–75mL/s154.7 (103.6–216.2)212.5 (123.2–301.9)0.01
PEFmL/s252.5 (180–355)282.5 (205–400)0.14
  • FEF25-75, forced expiratory flow between 25-75% of FVC; FEV, forced expiratory volume; FEV0.5/FEV0.75/FEV1.0, forced expiratory volume in 0.5/0.75/1.0 sec, maximum expiratory flow at 25% or 10% of FVC (MEF25/MEF10); IPFT, infants pulmonary function test; MTEF, mid tidal expiratory flow; PEF, peak expiratory flow; RTC, rapid thoracoabdominal compression; RVRTC, raised volume rapid thoracoabdominal compression; TBFVL, tidal breathing flow-volume loop; TEF10 or TEF25 or TEF 50/PTEF, ratio of TEF10, TEF25 or TEF50 to peaked tidal expiratory flow; TEF 10/TEF25/TEF50, tidal expiratory flow when 10/25 50 % of VT remaining for expiration; tPTEF/tE, the ratio of time to peak tidal expiratory flow to total expiratory time; Vʹmax, FRC, maximal flow at functional residual capacity; VT/Kg, tidal volume per unit bodyweight.