Prognosis scoring model to predict the survival of AE-IIP patients in the control arm
| (A) Stepwise selection of parameters to predict the survival of AE-IIP patients in the control arm using the multivariate Cox proportional hazard regression analysis | ||||
| ß coefficient | HR* | 95% CI | P value | |
| FDP/d-dimer, higher/lower | 1.557 | 4.949 | 2.111 to 11.600 | <0.001 |
| Prednisolone before AE, y/n | 0.969 | 2.636 | 1.161 to 5.984 | 0.020 |
| (B) Prognostic scoring model | |
| Parameters included in the model | Points |
| FDP/d-dimer, higher/lower | 3/0 |
| Prednisolone before AE, y/n | 2/0 |
| Total point score: poor/good prognostic stage† | 5, 3, 2/0 |
Higher FDP is 10 mg/L≤FDP and lower FDP is <10 mg/L as described in the section of Methods.
*HR >1 indicates worse survival.
†Receiver operation characteristics curve analysis was performed to reveal the cut-off values to predict cases with a poor prognosis with a lower frequency of 90-day survival. AE-IIP patients with a prognostic score of ≥2 were supposed to have a poor prognosis (poor prognostic stage).
AE, acute exacerbation; FDP, fibrin degradation product; higher/lower, higher vs lower; IIP, idiopathic interstitial pneumonia; y/n, yes vs no.