Prognostic factors associated with in-hospital mortality among hospitalised AECOPD patients by univariable and multivariable stratified Cox’s PH regression analysis with variance correction
| Prognostic factors | Univariable model | Multivariable model | ||
| Crude HR (95% CI) | P value | Adjusted HR (95% CI) | P value | |
| Age ≥80 years | 1.78 (1.05 to 3.03) | 0.032 | 2.16 (1.26 to 3.72) | 0.005 |
| Respiratory failure (intubation) | 2.26 (0.99 to 5.14) | 0.052 | 2.50 (1.12 to 5.57) | 0.025 |
| BT ≥38.0°C | 2.12 (1.21 to 3.69) | 0.008 | 2.97 (1.61 to 5.51) | 0.001 |
| MAP <65 mm Hg | 5.38 (2.44 to 11.87) | <0.001 | 4.01 (1.88 to 8.60) | <0.001 |
| WBC count ≥15 x 109/L | 2.39 (1.42 to 4.01) | 0.001 | 3.51 (1.90 to 6.48) | <0.001 |
| Neutrophil count ≥9 x 109/L | 1.36 (0.80 to 2.34) | 0.258 | – | – |
| Eosinophil count <0.05 x 109/L | 1.63 (0.95 to 2.80) | 0.077 | 1.61 (0.82 to 3.18) | 0.167 |
| Haemoglobin <120 g/L | 0.90 (0.52 to 1.56) | 0.714 | – | – |
| Serum creatinine ≥1.5 mg/dL | 2.19 (1.19 to 4.04) | 0.012 | 2.08 (1.17 to 3.70) | 0.013 |
| Blood urea nitrogen >20 mg/dL | 1.74 (0.99 to 3.04) | 0.053 | 1.55 (0.74 to 3.23) | 0.248 |
| Serum sodium <135 mmol/L | 1.21 (0.67 to 2.18) | 0.520 | – | – |
| Serum chloride <95 mmol/L | 1.38 (0.82 to 2.31) | 0.222 | – | – |
The models were adjusted for radiographic consolidation status and admission to the medical intensive care unit on admission.
AECOPD, acute exacerbation of chronic obstructive pulmonary disease; BT, body temperature; MAP, mean arterial pressure; WBC, white blood cell.