Table 3

Hepatic enzymes and renal function tests in patients with multidrug-resistant tuberculosis

Normal reference levelAt baseline3 months5–8 monthsP value
(baseline and
3 months)
P value
(baseline and 5–8 months)
Hepatic enzymes
 Alanine amino transferase,
 IU/L
5.0–40.017.0
(12.0–23.5)
(n=84)
12.0
(9.0–18.5)
(n=77)
15.0
(10.0–22.3)
(n=50)
0.004*0.302*
 Aspartate transaminase, IU/L5.0–37.026.0
(18.0–38.0)
(n=84)
27.0
(20.0–36.0)
(n=77)
30.0
(21.0–42.0)
(n=50)
0.516*0.445*
 Alkaline phosphatase, IU/L65.0–305.0180.0
(143.0–215.0)
(n=83)
171.0
(136.0–212.0)
(n=77)
179.5
(150.0–242.0)
(n=47)
0.211*0.488*
  Bilirubin total, µmol/L6.8–17.110.3
(8.6–11.9)
(n=84)
10.3
(8.6–11.9)
(n=77)
10.3
(8.6–11.9)
(n=49)
0.694*0.735*
  Bilirubin conjugated, µmol/L0.2–6.85.1
(3.4–5.1)
(n=80)
5.1
(3.4–5.1)
(n=74)
5.1
(3.4–5.1)
(n=46)
0.868*0.364*
Renal markers
 Creatinine, µmol/L
  Males n<12453.0–123.870.7
(61.8–79.5)
(n=86)
70.7
(61.8–79.5)
(n=85)
79.6
(61.8–88.4)
(n=82)
0.011†0.005†
  Females n<10744.2–106.8
 Potassium, mmol/L3.5–54.1
(3.8–4.4)
(n=86)
4.0
(3.8–4.4)
(n=84)
4.2
(3.9–4.5)
(n=85)
0.760†0.324†
 Sodium, mmol/L135–146143.0
(140.0–144.50)
(n=85)
144.0
(141.0–145.0)
(n=84)
144.0
(141.0–145.0)
(n=85)
0.006*0.130*
 Urea, mmol/L3.6–16.06.24
(5.4–8.2)
(n=83)
7.49
(5.7–10.4)
(n=85)
6.78
(5.7–9.3)
(n=82)
0.005*0.125*
 Uric acid, mmol/L
 M: n<0.42
 F: n<0.35
0.20–0.410.41
(0.33–0.53)
(n=78)
0.48
(0.41–0.59)
(n=78)
0.51
(0.39–0.59)
(n=80)
0.006†0.011†
  • Data are presented as median (IQR) for all continuous variables. Renal function was defined based on creatinine level. Creatinine level=132–194 µmol/L was considered impaired and >203 µmol/L was considered severely impaired; hyponatraemia=serum sodium below 135 mmol/L, severe hyponatraemia was less than 115 mmol/L; hypokalaemia=potassium less than 3.5 mmol/L; hyperkalaemia=potassium levels higher than 6 mmol/L. Hyperuricaemia=levels above the upper limit of normal for both males and females.

  • *Paired t-test.

  • †Wilcoxon signed-rank test.