Association between average total LSEQ score and delirium occurrence in the prior 24 hours after controlling for age, baseline severity of illness and nocturnal dexmedetomidine exposure (retrospective analysis)
| Variable | 24-hour periods where both LSEQ score and delirium assessment documented (n=439) | P value | Univariable analysis | Multivariable analysis | |||
| 24-hour periods with delirium (n=41) | 24-hour periods without delirium (n=398) | OR (95% CI) | P value | OR (95% CI) | P value | ||
| LSEQ 10-domain average | 5.5±1.1 | 5.4±1.1 | 0.94 | 1.01 (0.76 to 1.35) | 0.94 | 0.97 (0.71 to 1.30) | 0.79 |
| Age (years) | 67.4±8.1 | 63.2±11.4 | 0.02* | 1.04 (1.01 to 1.07) | 0.02* | 1.03 (0.99 to 1.06) | 0.14 |
| APACHE-II score | 25.8±7.1 | 22.2±8.1 | 0.01* | 1.06 (1.02 to 1.10) | 0.01* | 1.04 (1.00 to 1.09) | 0.05* |
| Dexmedetomidine (vs placebo) | 17 (41.5%) | 213 (53.5%) | 0.19 | 0.62 (0.32 to 1.18) | 0.14 | 0.68 (0.35 to 1.33) | 0.26 |
*P≤0.05.
APACHE, Acute Physiology and Chronic Health Evaluation; LSEQ, Leeds Sleep Evaluation Questionnaire.