Table 3

Comparing demographics data between intubation and non-progression groups

DemographicsIntubation (n=37)Non-intubation (n=67)P value
Age (years, mean±SD)63.9 (±11.67)58.9 (±14.17)0.06
Sex (F) n (%)16 (43.24 %)33 (49.25 %)0.55
BMI kg/m2 (mean±SD)31.0 (±6.74)32.8 (±8.33)0.27
Comorbidities n (%)
 Diabetes12 (33.33%)23 (35.38%)0.84
 Hypertension21 (56.76%)25 (38.46%)0.07
 Lung Dx14 (38.89%)17 (26.15%)0.18
 Heart Dx10 (27.03%)13 (20.00%)0.41
 CKD7 (21.21%)8 (13.56%)0.34
 Chronic haemodialysis4 (12.12%)5 (8.47%)0.57
Race
 African-American18 (48.65%)35 (52.24%)0.192
 Hispanic8 (21.62%)15 (22.62%)
 Caucasian6 (16.22%)3 (4.48%)
 Other04 (5.97%)
 Unknown5 (13.51%)10 (14.93%)
Smoking* n (%)
 No15 (41.67%)36 (57.14%)0.19
 Yes18 (50.00%)25 (39.68%)
Initial vitals
 HR (mean±SD)97.32 (±21.98)98.3 (±19.24)0.80
 RR (mean±SD)21.49 (±6.11)22.3 (±5.09)0.45
 Temperature (mean±SD)99.2 (±2.54)99.6 (±1.95)0.36
 Pulse oximetry (mean±SD)89.2 (±12.30)90.4 (±8.67)0.58
Laboratory abnormalities
 Mean (±SD)
 Ferritin (ng/mL)1078.2 (±1720.37)1290.5 (±3236.69)0.59
 CRP (mg/dL)12.51 (±10.02)11.35 (±7.38)0.90
 LDH (U/L)444.51 (±322.57)463.4 (±244.33)0.58
 D-dimer (ng/mL)9241.76 (±24519.18)3604.36 (±10938.11)0.36
 Fibrinogen (mg/dL)430.9 (±205.05)523.64 (±153.66)0.009
 Abs Lymph Ct (K/mm3)*1.05 (±0.43)1.00 (±0.50)0.39
 IL-6 (pg/mL)130.9 (±210.15)42.6 (±48.07)0.12
 AST (U/L)69.2 (±112.06)48.6 (±32.45)0.90
 ALT (U/L)39.78 (±43.54)37.85 (±22.89)0.51
 Platelets (K/mm3)215.2 (±115.74)225.5 (±101.02)0.60
 Triglycerides (mg/dL)293.96 (±454.58)145.26 (±75.86)0.52
 BUN (mg/dL)31.95 (±21.86)26.32 (±25.24)0.08
 Creatinine (mg/dL)2.88 (±3.58)2.46 (±4.15)0.09
 Treatments5 (13.89%)4 (7.02%)0.27
 Remdesivir trial*12 (33.33%)28 (42.42%)0.36
 Sarilumab trial†012 (18.18%)0.006
 Anakinra5 (13.89%%)1 (1.52%)0.011
 Tocilizumab1 (2.70%)00.18
 Etoposide11 (30.56%)8 (12.12%)0.02
 IVIG26 (72.22%)40 (60.61%)0.24
 Pulse steroids6 (16.67%)16 (24.24%)0.37
 Hydroxychloroquine12 (41.38%)22 (61.1%)0.30
 Azithromycin24 (64.86%)15 (22.39%)0.16
 Antibiotics
  • *Smoking—current vs former/non-smokers. NCT04292899 and NCT04292899.

  • NCT04315298.

  • Abs Lymph Ct, absolute lymphocyte count; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; BUN, blood urea Nitrogen; CKD, chronic kidney disease; CRP, C reactive protein; Dx, diagnosis; HD, haemodialysis; IL-6, interleukin 6; LDH, lactate dehydrogenase.