Top genetic associations of FN3K and FN3KRP tagging single nucleotide polymorphisms with six-minute walk distance (6MWD) in non-Hispanic Whites from Subpopulations and Intermediate Outcome Measures in COPD Study (MAF = Mean Allele Frequency)
| Non-Hispanic Whites (N=1827) | Mean 6MWD % predicted (SD) | |||||||
| rs number | Gene | Function | MAF | N=AA/AB/BB | A/A | A/B | B/B | P value |
| rs73361138 | FN3KRP | intron | 0.03 | 1729/96/2 | 84.1 (28.1) | 91.4 (27.8) | 78.7 (11.6) | 0.02 |
| rs1046875 | FN3KRP | 3UTR | 0.32 | 851/791/185 | 83.2 (26.0) | 84.8 (29.9) | 88.8 (28.9) | 0.02 |
| rs7794 | FN3KRP | 3UTR | 0.38 | 724/829/274 | 85.6 (29.1) | 84.9 (28.4) | 80.1 (23.9) | 0.008 |
| rs7208565 | FN3K | intron | 0.32 | 850/793/184 | 83.1 (25.9) | 85.0 (30.0) | 88.5 (29.0) | 0.01 |
| rs2263122 | FN3K | intron | 0.47 | 536/880/411 | 82.1 (24.3) | 85.2 (30.4) | 85.9 (27.4) | 0.02 |
COPD, chronic obstructive pulmonary disease; FN3K, fructosamine-3-kinase.