Comparison of the clinical characteristics at EGEA3 respective to the current asthma (CA) endotypes identified at EGEA2
| Number (No.) | CA1 versus CA2 | CA3 versus CA2 | |||
| No. events | OR (95% CI) | No. events | OR (95% CI) | ||
| Asthma attacks (last 12 months) | 314 | 20/134 | 1.08 (0.54 to 2.16) | 27/134 | 0.35 (0.19 to 0.62) |
| Exacerbations (last 12 months) | 258 | 13/65 | 2.19 (0.84 to 5.70) | 8/65 | 0.28 (0.12 to 0.65) |
| Asthma symptom score, last 12 months (0–5) (score more than 2 vs less or equal to 2) | 313 | 16/100 | 2.23 (1.02 to 4.91) | 15/100 | 0.20 (0.10 to 0.39) |
| Nocturnal symptoms (last 12 months) | |||||
| Cough | 275 | 22/116 | 3.48 (1.40 to 8.66) | 32/116 | 0.79 (0.46 to 1.37) |
| Chest tightness | 278 | 19/114 | 2.65 (1.09 to 6.48) | 28/114 | 0.41 (0.23 to 0.73) |
| Shortness of breath | 281 | 13/46 | 4.16 (1.64 to 10.5) | 9/46 | 0.40 (0.16 to 1.00) |
| Asthma control test (last 4 weeks) (score more or equal to 20 vs less than 20) | 282 | 17/58 | 3.43 (1.54 to 7.61) | 9/58 | 0.42 (0.50 to 0.97) |
| Dyspnoea grade 3 | 328 | 19/72 | 3.52 (1.64 to 7.57) | 12/72 | 0.46 (0.22 to 0.97) |
Data are expressed as adjusted OR with a 95% CI.
Endotype CA2 was the reference (OR=1).
OR (95% CI) were adjusted on age, sex and current smoking status at EGEA2, taking into account familial dependence of the participants.
*†‡§Results did change after further adjustment on BMI for asthma symptom score OR=2.18 (0.98 to 4.82), shortness of breath OR=0.43 (0.17 to 1.08), asthma control test OR=0.45 (0.19 to 1.02), and dyspnoea OR=0.51 (0.24 to 1.09).
Dyspnoea grade 3 was defined according to the Medical Research Council scale.