Table 4

Crude and adjusted quantile regression (50th) analysis of lung function by surfactant composition (lipids and proteins) among healthy groups, ECRHS-III (n=200)

Explanatory variablesFEV1 (%pred)
coefficient (95% CI)
FVC (%pred)
coefficient (95% CI)
FEV1/FVC
coefficient (95% CI)
CrudeAdjustedCrudeAdjustedCrudeAdjusted
DPPC (wt%)−0.01 (−0.08 to 0.06)−0.03 (−0.10 to 0.04)−0.03 (−0.11 to 0.06)0.03 (0.01 to 0.06)*0.16 (0.002 to 0.31)*0.25 (0.10 to 0.40)*
POPC (wt%)−0.02 (−0.24 to 0.20)−0.12 (−0.36 to 0.11)−0.09 (−0.37 to 0.20)0.14 (0.06 to 0.22)*0.45 (0.06 to 0.95)*0.91 (0.42 to 1.42)*
PC14:0/16:0 (%)0.02 (−0.01 to 0.05)0.02 (0.001 to 0.03)*0.04 (0.001 to 0.08)*0.02 (0.001 to 0.04)*0.08 (−0.15 to −0.01)*−0.04 (−0.08 to 0.001)
PC16:0/18:2 (%)0.01 (−0.06 to 0.08)0.03 (−0.05 to 0.10)0.01 (−0.08 to 0.11)0.04 (−0.06 to 0.13)−0.10 (−0.25 to 0.07)−0.01 (−0.10 to 0.08)
SP-A (wt%)0.03 (−0.10 to 0.15)0.01 (−0.06 to 0.07)0.09 (−0.08 to 0.25)0.13 (−0.06 to 0.33)0.09 (−0.20 to 0.37)0.04 (−0.06 to 0.13)
Albumin (wt%)−0.02 (−0.07 to 0.02)−0.02 (−0.05 to 0.01)−0.03 (−0.10 to 0.03)−0.03 (−0.10 to 0.03)−0.06 (−0.19 to 0.06)−0.04 (−0.04 to 0.08)
  • Significant associations (*) are also marked in bold.

  • DPPC, di-palmitoyl-di-phosphatidyl-choline; ECRHS-III, European Community Respiratory Health Survey III; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; PC, phosphatidylcholine; SP-A, surfactant protein A.