Summary of the univariate analysis results for the association between the various prognostic factors and survival
| Variable | N | Category/term | HR (95% CI) | P value |
| Age at diagnosis* | 100 | Linear term | 1.34 (1.15 to 1.54) | <0.001 |
| Squared term | 1.07 (1.00 to 1.14) | |||
| Gender | 100 | Male | 1 | 0.93 |
| Female | 1.03 (0.59 to 1.79) | |||
| Weight† | 70 | – | 0.82 (0.70 to 0.95) | 0.009 |
| BMI* | 48 | – | 0.71 (0.52 to 0.96) | 0.03 |
| Asbestos exposure | 89 | No | 1 | 0.36 |
| Yes | 1.27 (0.76 to 2.14) | |||
| Smoking status | 94 | Non-smoker | 1 | 0.08 |
| Ex-smoker | 1.53 (0.93 to 2.53) | |||
| Current smoker | 2.20 (1.07 to 4.51) | |||
| Performance status (PS) | 95 | 0 | 1 | <0.001 |
| 1 | 1.32 (0.79 to 2.22) | |||
| 2+ | 3.21 (1.80 to 5.74) | |||
| Respiratory | 98 | No | 1 | 0.47 |
| Comorbidity | Yes | 1.22 (0.72 to 2.07) | ||
| Other comorbidity | 98 | No | 1 | 0.47 |
| Yes | 1.18 (0.75 to 1.86) | |||
| No of comorbidities | 98 | 0 | 1 | 0.12 |
| 1 | 1.10 (0.64 to 1.87) | |||
| 2+ | 1.65 (0.96 to 2.84) | |||
| Dyspnoea | 99 | No | 1 | 0.01 |
| Yes | 0.49 (0.27 to 0.86) | |||
| Chest pain | 99 | No | 1 | 0.03 |
| Yes | 1.60 (1.05 to 2.43) | |||
| Cough | 99 | No | 1 | 0.72 |
| Yes | 0.93 (0.61 to 1.40) | |||
| Weight loss | 99 | No | 1 | <0.001 |
| Yes | 2.37 (1.55 to 3.62) | |||
| Loss of appetite | 99 | No | 1 | 0.15 |
| Yes | 1.35 (0.90 to 2.04) | |||
| Night sweats | 99 | No | 1 | 0.36 |
| Yes | 1.32 (0.73 to 2.38) | |||
| Fever | 99 | No | 1 | 0.46 |
| Yes | 0.59 (0.14 to 2.40) | |||
| Histological | 94 | Epithelioid | 1 | 0.51 |
| Subtype | Non-epithelioid | 1.20 (0.71 to 2.02) | ||
| Unclassified | 1.44 (0.73 to 2.83) | |||
| Malignant cells (cytology) | 65 | No | 1 | 0.68 |
| Yes | 1.13 (0.63 to 2.00) | |||
| Hb | 99 | – | 0.77 (0.68 to 0.88) | <0.001 |
| RDW | 99 | – | 1.12 (0.99 to 1.26) | 0.07 |
| PLT‡ | 99 | Linear term | 1.02 (0.91 to 1.14) | <0.001 |
| Squared term | 1.04 (1.01 to 1.07) | |||
| WCC | 99 | – | 1.00 (0.94 to 1.07) | 0.91 |
| NLR* | 99 | – | 0.97 (0.078 to 1.20) | 0.79 |
| CRP‡ | 66 | – | 0.94 (0.379 to 1.12) | 0.51 |
| Urea* | 98 | – | 1.31 (1.03 to 1.67) | 0.03 |
| Na* | 98 | – | 1.00 (0.73 to 1.38) | 0.98 |
| K | 96 | Linear term | 1.45 (0.91 to 2.29) | 0.03 |
| Squared term | 2.21 (1.09 to 4.49) | |||
| Creatinine§ | 98 | Linear term | 0.71 (0.11 to 0.57) | 0.006 |
| Squared term | 40 042 (9.2 to 1 768 852) | |||
| Total protein* | 92 | – | 0.98 (0.83 to 1.17) | 0.83 |
| Albumin* | 92 | – | 0.70 (0.55 to 0.88) | 0.003 |
| ALP§ | 92 | – | 2.21 (0.70 to 6.98) | 0.18 |
| Adjusted calcium¶ | 80 | – | 1.37 (1.10 to 1.70) | 0.005 |
| Phosphate¶ | 77 | – | 0.92 (0.81 to 1.05) | 0.21 |
| Pleural fluid protein* | 49 | – | 0.96 (0.80 to 1.13) | 0.6 |
| Pleural fluid LDH§ | 52 | – | 4.26 (1.66 to 11.0) | 0.003 |
For categorical predictor variables, the HRs give the risk of death in each category relative to the risk in a baseline category. For continuous predictor variables, the HRs give the relative change in the risk of death at any time for an increase in that variable.
*HRs reported for a 5-unit increase in variable.
†HRs reported for a 10-unit increase in variable.
‡HRs reported for a 50-unit increase in variable.
§Variable analysed on a log scale (base 10).
¶HRs reported for a 0.1-unit increase in variable.