Baseline characteristics of healthy controls and patients with IPF
| Healthy controls (n=26) | Patients with IPF | ||
| Derivation cohort (n=26) | Validation cohort (n=66) | ||
| Sex, men | 14 (54%) | 24 (92%) | 59 (89%) |
| Age, years | 47.6 (12) | 69.6 (11.5) | 71.3 (7.1) |
| BMI, kg/m2 | 24.4 (3.4) | 26.2 (3.1) | 28.6 (3.6) |
| Ever-smokers | 14 (54%) | 20 (77%) | 47 (71%) |
| Pack-years | 4.5 (0–15) | 30 (20–40) | 20 (0–35) |
| Diabetes | 17 (26%) | ||
| Dyslipidaemia | 29 (44%) | ||
| DLCO, % predicted | 89.4 (11.1) | 44.3 (15.2) | 53.7 (16.9) |
| FVC, % predicted | 101.8 (10.4) | 62.4 (16.1) | 81.7 (17.9) |
| FEV1, % predicted | 95.9 (10.7) | 73.5 (11) | 83.6 (17.2) |
| CPI | 11.6 (8.9) | 50.5 (11.2) | 41.0 (14.2) |
| Calprotectin, µg/mL | 0.89 (0.57–1.12) | 2.16 (1.12–2.85) | 2.90 (1.60–3.78) |
Data expressed in number (percentage), mean (SD) or median (IQR).
BMI, body mass index; CPI, Composite Physiological Index; DLCO, diffusing capacity for carbon monoxide; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; IPF, idiopathic pulmonary fibrosis.