Table 1

Classification of exposure categories and regimens

Exposure categories and regimensProducts included in regimen
LAMA and LABA dual therapy
 LAMA+LABA/ICSConcurrent use of LAMA single-agent product and LABA/ICS combination product
 LAMA+LABA+ICSConcurrent use of three single-agent products (LAMA, LABA and ICS)
 LAMA+LABAConcurrent use of LAMA and LABA single-agent products
LAMA therapy
 LAMAUse of LAMA single-agent product only
 LAMA+ICSConcurrent use of LAMA and ICS single-agent products
LABA therapy
 LABAUse of LABA single-agent product only
 LABA+ICSConcurrent use of LABA and ICS single-agent products
 LABA/ICSUse of LABA/ICS combination product only
ICS monotherapy*
 ICSUse of ICS single-agent product only
  • *By design, all cohort members had used a long-acting bronchodilator before the episode of ICS monotherapy.

  • ICS, Inhaled corticosteroid; LABA, long-acting beta2 agonist; LAMA, long-acting muscarinic antagonist.