Baseline characteristics of the antifibrotic group compared with the control group
| Characteristics | Antifibrotic (n=104) | Control (n=64) | P value |
| Male sex, n (%) | 79 (76.0) | 49 (76.6) | 0.929 |
| Age (years), median (IQR) | 72 (12) | 78 (12) | <0.001 |
| Smoking status, n (%) | 0.354 | ||
| Never | 33 (32.4) | 20 (31.3) | |
| Ex-smoker | 67 (65.7) | 40 (62.5) | |
| Current smoker | 2 (2.0) | 4 (6.25) | |
| Smoking pack-years, median (IQR) | 11 (25) | 13 (35) | 0.470 |
| Weight (kg), mean (SD) | 79.9 (17.5) | 76.9 (14.5) | 0.253 |
| BMI, median (IQR) | 28.48 (5.48) | 26.85 (5.77) | 0.122 |
| External referral, n (%) | 57 (54.8) | 21 (32.8) | 0.006 |
| Oxygen therapy (%) | |||
| LTOT | 8 (7.7) | 5 (7.8) | 0.977 |
| Ambulatory | 15 (14.4) | 5 (7.8) | 0.199 |
| Previous triple therapy, n (%) | 5 (4.8) | 2 (3.1) | 0.596 |
| Previous corticosteroid therapy, n (%) | 20 (19.2) | 4 (6.3) | 0.020 |
| Histological diagnosis, n (%) | 16 (15.4) | 5 (7.8) | 0.150 |
| FVC (L), mean (SD) | 2.26 (0.51) | 2.31 (0.53) | 0.520 |
| FVC % predicted, median (IQR) | 67.0 (14.5) | 71.0 (11.2) | 0.015 |
| DLco (mmol/min/kPa), median (IQR) | 3.36 (1.48) | 3.11 (1.63) | 0.343 |
| DLco % predicted, mean (SD) | 43.0 (12.6) | 42.1 (14.3) | 0.694 |
| Kco (mmol/min/kPa/L), mean (SD) | 1.07 (0.31) | 0.99 (0.32) | 0.120 |
| Kco % predicted, mean (SD) | 80.4 (23.7) | 77.4 (23.2) | 0.447 |
| SpO2 (%), median (IQR) | 94 (4) | 95 (6) | 0.597 |
| Emphysema on HRCT, n (%) | 14 (13.5) | 13 (20.3) | 0.240 |
BMI, Body Mass Index; DLco, diffusion capacity for carbon monoxide; DLCO, diffusion capacity for carbon monoxide percentage; FVC, forced vital capacity percentage; FVC, forced vital capacity; HRCT, High resolution Computed tomography scan; IQR, interquartile range; Kco, carbon monoxide transfer coefficient; SpO2, pulse oximetry.