Medical therapy | Overall (N=4313) | Survivors (n=3043) | Non-survivors (n=1270) | P value |
Corticosteroids—n (%) | 574 (13.3) | 421 (13.8) | 153 (12.1) | 0.13 |
Medication | ||||
Methylprednisolone | 282 (49.1) | 199 (73.3) | 83 (54.2) | 0.99 |
Prednisone | 139 (24.2) | 109 (25.9) | 30 (19.6) | 0.04 |
Dexamethasone | 82 (14.3) | 62 (14.7) | 20 (13.1) | 0.33 |
Hydrocortisone | 71 (12.4) | 51 (12.1) | 20 (13.1) | 0.89 |
Duration of use (days)* | ||||
Methylprednisolone | 6.63 (3.45–11.48) | 4.99 (2.89–8.33) | 5.80 (3.68–8.26) | 0.72 |
Prednisone | 8.59 (2.97–21.46) | 4.94 (2.29–12.87) | 8.15 (1.81–19.59) | 0.29 |
Dexamethasone | 6.34 (2.63–12.78) | 5.04 (2.48–6.98) | 3.72 (2.42–5.45) | 0.32 |
Hydrocortisone | 9.53 (4.88–14.28) | 9.59 (4.25–12.94) | 8.16 (3.45–12.06) | 0.92 |
Timing of corticosteroid initiation | ||||
<7 days | 330 (57.6) | 244 (58.0) | 86 (56.1) | 0.52 |
≥8 to ≤14 days | 129 (22.6) | 92 (21.9) | 37 (24.2) | |
>14 days | 115 (20.1) | 85 (18.0) | 30 (19.6) | |
Median time from hospital admission to corticosteroid administration (days) | 5.96 (3.08–10.62) | 5.86 (2.97–10.51) | 6.25 (3.58–11.29) | 0.58 |
Adjuvant therapies among corticosteroid users | ||||
Hydroxychloroquine | 420 (73.2) | 321 (76.2) | 99 (64.7) | 0.74 |
Azithromycin | 397 (69.2) | 289 (68.7) | 108 (70.6) | 0.55 |
Tocilizumab | 20 (3.5) | 13 (3.1) | 7 (4.6) | 0.62 |
Anticoagulation | 255 (44.4) | 191 (45.3) | 65 (42.4) | 0.55 |
*Median time of drug administration—(25% percentile–75% percentile).
†Anticoagulation—heparin, enoxaparin, apixaban, rivaroxaban.