Table 3

Completion rates for questionnaires and other outcomes performed during the study

OutcomeExpected data points—nMissing data points—n (%)
FAS1652 (1.2)
FACIT-Fatigue1652 (1.2)
HADS1214 (3.3)
KSQ1213 (2.5)
EQ5D1213 (2.5)
SF361214 (3.3)
Safety*1045 (4.8)
PSQI†432 (4.7)
Spirometry (FEV1 and FVC)‡603 (5.0)
MSWT§607 (11.7)
Activity monitor data¶603 (5.0)
Total114230 (2.6)
  • *Safety questionnaire was administered up to week 12; participants completing a truncated time period who completed study medications at week 12 did not all receive safety questionnaires at their final visit (4 out of 5 missing data points).

  • †PSQI only administered following major amendment approved in April 2017; expected data points refers to the number of visits where the questionnaire should have been administered after the study amendment was approved.

  • ‡All missing spirometry values occurred in a single participant who was unable to perform the test without suffering syncope.

  • §Six of the seven missing MSWT values occurred due to loss of facilities to undertake the test.

  • ¶Missing data points for activity watches refers to an unreturned device (one missing data point) or device not worn during wear period (two missing data points).

  • EQ5D, EuroQoL 5 Dimension 5 Level scale; FACIT-Fatigue, Functional Assessment of Chronic Illness Therapy-Fatigue; FAS, Fatigue Assessment Scale; FEV1, forced expiratory volume in 1s; HADS, Hospital Anxiety and Depression Scale; KSQ, Kings Sarcoidosis Questionnaire; MSWT, modified shuttle walk test; PSQI, Pittsburgh Sleep Quality Index; SF36, Short Form 36.