Examples of predicted probabilities of survival to 12, 24 and 36 months for the T12 cohort (ie, for people surviving to 12 months after baseline): three different hypothetical examples of people with extreme combinations of covariables
| Scenarios (covariables) | Predicted probability of survival to 12 months given covariables X (95% CI) | Predicted probability of survival to 24 months given covariables X (95% CI) | Predicted probability of survival to 36 months given covariables X (95% CI) |
| Deterioration in FEV1 (T12–T0) >10%; Combination of insurance (Medicaid); No oxygen therapy; Depression; 4 or more pulmonary exacerbations in the year preceding advanced stage CF diagnosis; 4 or more interim pulmonary exacerbations (T0–T12); No lung transplant in the past 12 months (n=7) | 79.2% (69.3% to 84.1%) | 64.1% (49.9% to 71.2%) | 50.8% (33.8% to 59.4%) |
| Improvement in FEV1 (T12–T0) >10%; Combination of insurance (Medicaid); Continuous oxygen therapy; No depression; 4 or more pulmonary exacerbations in the year preceding advanced stage CF diagnosis 4 or more interim pulmonary exacerbations (T0–T12); No lung transplant in the past 12 months (n=25) | 86.2% (82.4% to 90.9%) | 75.3% (68.9% to 83.9%) | 64.9% (57.7% to 75.5%) |
| Improvement in FEV1 (T12–T0) >10%; Private insurance only; No oxygen therapy; No depression No pulmonary exacerbations in the year preceding advanced stage CF diagnosis; No interim pulmonary exacerbations (T0–T12); No lung transplant in the past 12 months (n=128) | 95.2% (94.5% to 97.9%) | 91.0% (90.1% to 95.8%) | 86.6% (84.7% to 93.4%) |
n=X represents the number of people with the combinations of covariables in the dataset.
CF, cystic fibrosis; FEV1, forced expiratory volume in 1 s.