Table 3A

Examples of predicted probabilities of survival to 12, 24 and 36 months for the T0 cohort (ie, after baseline incident advanced CF): three different hypothetical examples of people with extreme combinations of covariables

Scenarios (covariables)Predicted probability of survival to 12 months given covariables X (95% CI)Predicted probability of survival to 24 months given covariables X (95% CI)Predicted probability of survival to 36 months given covariables X (95% CI)
FEV1 15% predicted;
Combination of insurance (Medicaid);
Non-smoker;
No non-invasive ventilation;
Continuous oxygen therapy;
No Burkholderia species
No liver disease;
Depression;
No renal failure requiring dialysis;
Mutation class: 1–3;
4 or more pulmonary exacerbations in the year preceding advanced stage CF diagnosis;
Baseline lung transplant evaluation status: not pertinent
(n=3)		77.9% (71.6% to 83.2%)58.2% (48.3% to 65.7%)43.5% (32.7% to 51.2%)
FEV1 25% predicted;
Combination of insurance (Medicaid);
Non-smoker;
No non-invasive ventilation;
Continuous oxygen therapy;
No Burkholderia species;
No liver disease;
No depression;
No renal failure requiring dialysis;
Mutation class: 1–3;
4 or more pulmonary exacerbations in the year preceding advanced stage CF diagnosis;
Baseline lung transplant evaluation status: not pertinent
(n=21)		86.7% (83.4% to 90.1%)73.4% (68.2% to 77.5%)62.2% (55.6% to 66.9%)
FEV1 40 (%) predicted;
Private insurance only;
Non-smoker;
No non-invasive ventilation;
No oxygen therapy;
No Burkholderia species;
No liver disease
No depression;
No renal failure requiring dialysis;
Mutation class: 1–3,
0 pulmonary exacerbations in the year preceding advanced stage CF diagnosis;
Baseline lung transplant evaluation status: not pertinent
(n=131)		97.3% (96.7% to 98.1%)94.1% (92.9% to 95.8%)90.8% (88.9% to 93.1%)

  • n=X represents the number of people with the combinations of covariables in the dataset.

  • CF, cystic fibrosis; FEV1, forced expiratory volume in 1 s.