Lung function trait (exposure) | |||||
FEV1, FVC, FEV1/FVC, PEF | FEV1 | FVC | FEV1/FVC | ||
No. SNPs used | 131 | 42 | 46 | 73 | |
IVW | OR per SD | 1.02 | 1.04 | 1.08 | 0.99 |
95% CI | 0.91 to 1.13 | 0.82 to 1.32 | 0.85 to 1.37 | 0.88 to 1.13 | |
P value | 0.68 | 0.73 | 0.51 | 0.97 | |
Q_p-value* | 0.26 | 0.30 | 0.19 | 0.71 | |
Weighted median | OR per SD | 1.01 | 1.15 | 1.14 | 0.95 |
95% CI | 0.86 to 1.19 | 0.82 to 1.61 | 0.83 to 1.58 | 0.79 to 1.15 | |
P value | 0.81 | 0.39 | 0.39 | 0.62 | |
Weighted mode | OR per SD | 0.99 | 1.07 | 1.04 | 0.97 |
95% CI | 0.78 to 1.26 | 0.60 to 1.90 | 0.61 to 1.78 | 0.74 to 1.26 | |
P value | 0.97 | 0.80 | 0.86 | 0.84 | |
MR Egger | OR per SD | 1.05 | 1.22 | 0.97 | 0.95 |
95% CI | 0.79 to 1.34 | 0.57 to 2.59 | 0.36 to 2.62 | 0.69 to 1.31 | |
P value | 0.71 | 0.59 | 0.96 | 0.77 |
*A test for heterogenity. If this was <0.05 it would suggest heterogenity.
FEV, forced expiratory volume; FVC, forced expiratory volume; IVW, inverse variance weighting; MR, Mendelian randomisation; PEF, peak expiratory flow; SNPs, single nucleotide polymorphisms.