Table 6

Prognostic significance of an increase in serum cytokine levels at day 8 from baseline levels for AE-IIPs: logistic regression analysis of 90-day mortality

Parameters	OR*	95% CI	P value
Univariate analysis
ΔIL-ra	1.0003	0.9987 to 1.0038	0.7276
ΔIL-2	6.5971	0.2441 to 453.9501	0.2575
ΔIL-4	0.1854	0.000223 to 68.6763	0.5734
ΔIL-5	1.1894	0.7046 to 2.1647	0.4765
ΔIL-6	2.1743	0.8055 to 14.1524	0.1614
ΔIL-7	12.6586	1.5148 to 407.2435	0.0130
ΔIL-8	1.0164	0.9928 to 1.0842	0.3159
ΔIL-9	3.7582	0.9318 to 34.8311	0.0692
ΔIL-10	489.7742	5.4452 to 3 967 492	0.0002
ΔIL-12	0.9146	0.0764 to 4.1373	0.9122
ΔIL-13	0.3314	0.0034 to 4.5552	0.4703
ΔIL-17	0.7084	0.0691 to 4.7883	0.7327
ΔEotaxin/CCL11	0.9306	0.8249 to 1.0037	0.0657
Δb-FGF	1.4213	0.7410 to 2.9857	0.2883
ΔG-CSF	1.2878	1.0029 to 2.1824	0.0418
ΔGM-CSF	2.6346	0.0085 to 996.8476	0.7260
ΔIFNγ	24.2498	1.7469 to 4292.726	0.0063
ΔIP-10/CXCL10	1.0002	0.9986 to 1.0018	0.7270
ΔMCP-1/CCL2	1.4248	1.0812 to 2.2406	0.0009
ΔMIP-1α/CCL3	2.4528	0.9378 to 28.5121	0.1541
ΔPDGF-BB	1.0104	0.9931 to 1.0346	0.2433
ΔMIP-1β/CCL4	1.0048	0.9970 to 1.0211	0.2765
ΔRANTES/CCL5	1.0001	0.9999 to 1.0007	0.2813
ΔTNF-α	2.1615	0.9022 to 7.3186	0.0918
Multivariate analysis†
ΔIL-10	489.7	5.445 to 3 967 492	0.0002

*OR >1 means an increase in each parameter (pg/mL) indicating a high risk of 90-day mortality.
†Multivariate logistic regression analysis with stepwise selection was performed using five significant (p<0.05) cytokines by univariate analysis: ΔIL-7, ΔIL10, ΔG-CSF, ΔIFN-γ and ΔMCP-1.
b-FGF, basic fibroblast growth factor; CCL, CC chemokine ligand; CXCL, CXC chemokine ligand; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; IIPs, idiopathic interstitial pneumonias; IL, interleukin; IP-10, IFN-γ inducible protein; MCP, monocyte chemotactic protein; MIP, macrophage inflammatory protein; PDGF, platelet-derived growth factor; RANTES, regulated on activation, normal T cell expressed and secreted; TNF, tumour necrosis factor.