Univariable and multivariable regression analysis of the determinants of non-adherence (TAI <50)
| Variable | Non-adherent patients/total (%) | OR (95% CI) | P value | aOR (95% CI) | P value |
| Age (years) | 0.96 (0.93 to 0.99) | 0.017 | 0.98 (0.94 to 1.01) | 0.228 | |
| Respiratory diagnosis | |||||
| Asthma | 14/31 (45) | Ref. | |||
| COPD | 8/27 (30) | 0.51 (0.17 to 1.52) | 0.227 | ||
| ACO | 5/12 (42) | 0.87 (0.23 to 3.34) | 0.836 | ||
| Multiple vs single device | 13/32 (41) vs 14/38 (37) | 1.17 (0.45 to 3.08) | 0.746 | ||
| Quality of life | 1.00 (0.96 to 1.03) | 0.759 | |||
| High vs low education | 17/42 (40) vs 10/28 (36) | 1.22 (0.46 to 3.29) | 0.689 | ||
| Poor treatment knowledge | 17/40 (43) vs 10/30 (33) | 1.48 (0.55 to 3.96) | 0.436 | 2.89 (0.81 to 10.24) | 0.100 |
| Adverse drug events vs no | 11/30 (37) vs 16/40 (40) | 0.87 (0.33 to 2.30) | 0.777 | ||
| Smoking status | |||||
| Never | 14/24 (58) | Ref. | Ref. | ||
| Past | 10/32 (31) | 0.32 (0.11 to 0.98) | 0.046 | 0.32 (0.07 to 1.40) | 0.130 |
| Current | 3/14 (21) | 0.19 (0.04 to 0.88) | 0.034 | 0.15 (0.02 to 0.96) | 0.045 |
Significant estimates (p<0.05) are indicated in bold.
*Nagelkerke R2: 0.210; Hosmer and Lemeshow goodness-of-fit test p value: 0.376; correctly classified: 71.4%.
ACO, asthma-COPD overlap; aOR, adjusted OR; ; COPD, chronic obstructive pulmonary disease; TAI, Test of the Adherence to Inhalers.