Ventilator parameters of intubated patients with COVID-19 by obesity class
| Values (days 1, 3 and 7) | Underweight (BMI <18.5 kg/m2) n=5 | Normal weight (BMI 18.5–24.9 kg/m2) n=66 | Overweight (BMI 25.0–29.9 kg/m2) n=76 | Obese (BMI 30.0–39.9 kg/m2) n=97 | Morbidly obese (BMI >40.0 kg/m2) n=16 |
| PEEP (cm H2O) | |||||
| PEEP 1 | 10.0 (8.0–10.0) | 10.0 (8.0–10.0) | 10.0 (10.0–12.0) | 10.0 (10.0–12.0) | 14.0 (10.0–15.0) |
| PEEP 3 | 8.0 (8.0–9.0) | 10.0 (8.0–12.0) | 12.0 (8.0–12.0) | 12.0 (10.0–14.0) | 14.0 (10.0–15.0) |
| PEEP 7 | 8.0 (7.0–9.0) | 10.0 (8.0–13.0) | 10.0 (8.0–12.0) | 12.0 (8.0–14.0) | 12.0 (10.0–14.5) |
| Plateau pressure (cm H2O) | |||||
| Plateau pressure 1 | 24.5 (21.2–27.8) | 23.5 (20.0–27.0) | 24.0 (21.0–28.0) | 26.0 (21.0–30.0) | 30.0 (27.0–30.0) |
| Plateau pressure 3 | 23 (22–24) | 24 (19–27) | 24 (20–28) | 25 (22–29) | 27 (23–33) |
| Plateau pressure 7 | 44.0 (44.0–44.0) | 27.0 (22.5–30.8) | 26.0 (22.0–28.0) | 24.0 (22.5–28.5) | 27.0 (22.0–30.0) |
| PaO2/FiO2 ratio | |||||
| PaO2/FiO2 ratio 1 | 188 (152–207) | 116 (84–160) | 108 (91–146) | 115 (84–151) | 96 (62–129) |
| PaO2/FiO2 ratio 3 | 134 (124–144) | 128 (105–180) | 148 (110–174) | 140 (110–168) | 103 (83–147) |
| PaO2/FiO2 ratio 7 | 200 (200–200) | 141 (93–172) | 138 (109–160) | 142 (116–179) | 154 (112–186) |
| Tidal volume per predicted body weight (PBW; ml/kg) | |||||
| Tidal volume/PBW 1 | 5.53 (5.29–5.95) | 6.74 (6.26–7.76) | 6.97 (6.15–8.38) | 7.34 (6.42–8.21) | 8.02 (7.43–9.66) |
| Tidal volume/PBW 3 | 5.29 (5.17–5.62) | 6.21 (5.95–6.82) | 6.68 (6.06–7.13) | 6.57 (6.03–7.03) | 7.02 (6.26–7.73) |
| Tidal volume/PBW 7 | 5.05 (5.05–5.05) | 6.43 (5.97–7.02) | 6.70 (6.15–7.49) | 6.83 (6.27–7.60) | 6.97 (6.76–7.30) |
| Static compliance (mL/cm H2O) | |||||
| Static compliance 1 | 29 (20–36) | 30 (22–39) | 29 (23–40) | 28 (22–38) | 29 (27–36) |
| Static compliance 3 | 25 (24–29) | 30 (24–38) | 29 (23–39) | 31 (22–39) | 31 (23–35) |
| Static compliance 7 | 11 (11–11) | 25 (20–33) | 31 (21–39) | 28 (24–37) | 25 (22–36) |
| Driving pressure (cm H2O) | |||||
| Driving pressure 1 | 9.5 (8.8–10.2) | 12.2 (10.0–16.0) | 14.0 (11.0–18.0) | 14.0 (11.0–19.0) | 15.0 (14.0–17.0) |
| Driving pressure 3 | 14.0 (13.0–15.0) | 12.0 (10.0–16.0) | 12.0 (10.0–15.2) | 13.0 (9.5–16.0) | 15.5 (12.0–18.2) |
| Driving pressure 7 | 34.0 (34.0–34.0) | 15.0 (12.2–17.5) | 13.0 (11.0–17.0) | 13.0 (11.2–17.0) | 14.0 (8.0–16.0) |
| Ventilatory ratio | |||||
| Ventilatory ratio 1 | 1.27 (1.22–1.44) | 1.63 (1.24–2.18) | 1.88 (1.64–2.23) | 1.87 (1.54–2.49) | 2.21 (1.84–2.59) |
| Ventilatory ratio 3 | 1.44 (1.17–1.44) | 1.72 (1.43–2.10) | 2.03 (1.62–2.60) | 2.17 (1.73–2.65) | 2.22 (1.96–2.51) |
| Ventilatory ratio 7 | 0.99 (0.99–0.99) | 1.80 (1.52–2.34) | 2.19 (1.68–2.63) | 2.26 (1.88–2.64) | 2.39 (1.98–3.03) |
Statistics presented: median (25–75th percentile, IQR).
PEEP, plateau pressure, extrinsic positive end expiratory pressure.