Physiological parameters at CPAP initiation stratified by escalation status
| Variable | For escalation to IMV (n=56) | CPAP ceiling of care* (n=32) | Whole cohort (n=88) |
| Respiratory rate pre-CPAP (median, IQR) | 30 (25–36) | 29 (24–34) | 30 (25–35) |
| Fio2 pre-CPAP (median, IQR) | 100 (60–100) | 100 (60–100) | 100 (60–100) |
| SpO2 pre-CPAP | 93 (91–95) | 92 (88–94) | 92 (90–95) |
| SpO2/FiO2 ratio | 95 (92–153) | 94 (89–151) | 95 (92–152) |
| Initial CPAP (cmH2O) | 10 (7.5–10) | 10 (7.5–10) | 10 (7.5–10) |
| Maximum CPAP (cmH2O) | 10 (7.5–10) | 10 (10–10) | 10 (8.8–10) |
| Initial oxygen (L/min) | 15 (10–15) | 15 (12–18) | 15 (10–15) |
| Enrolled in therapeutic clinical trials | RECOVERY 19 (34%) Other† 12 (21%) | RECOVERY 8 (25%) Other† 0 (0%) | RECOVERY 27 (31%) Other† 12 (14%) |
*CPAP as ceiling care. The patient was not deemed clinically appropriate for mechanical ventilation.
†Others are REMAP-CAP, OSCAR or REALIST.
CPAP, continuous positive airway pressure; IMV, invasive mechanical ventilation.