Table 2

Physiological parameters at CPAP initiation stratified by escalation status

VariableFor escalation to IMV
(n=56)
CPAP ceiling of care*
(n=32)
Whole cohort
(n=88)
Respiratory rate pre-CPAP (median, IQR)30 (25–36)29 (24–34)30 (25–35)
Fio2 pre-CPAP (median, IQR)100 (60–100)100 (60–100)100 (60–100)
SpO2 pre-CPAP93 (91–95)92 (88–94)92 (90–95)
SpO2/FiO2 ratio95 (92–153)94 (89–151)95 (92–152)
Initial CPAP (cmH2O)10 (7.5–10)10 (7.5–10)10 (7.5–10)
Maximum CPAP (cmH2O)10 (7.5–10)10 (10–10)10 (8.8–10)
Initial oxygen (L/min)15 (10–15)15 (12–18)15 (10–15)
Enrolled in therapeutic clinical trialsRECOVERY 19 (34%)
Other† 12 (21%)
RECOVERY 8 (25%)
Other† 0 (0%)
RECOVERY 27 (31%)
Other† 12 (14%)
  • *CPAP as ceiling care. The patient was not deemed clinically appropriate for mechanical ventilation.

  • †Others are REMAP-CAP, OSCAR or REALIST.

  • CPAP, continuous positive airway pressure; IMV, invasive mechanical ventilation.