Table 1

Clinical features, histological features, Crs and steroid treatment seen in preterm infants and observed in patients with COVID-19 ARDS and as reported by Grasselli et al.3 See text for details

Neonatal RDSCOVID-19 ARDS
Clinical featuresTachypnoea, increased work of breathing and hypoxiaDyspnoea, tachypnoea and hypoxia
Histological featuresDiffuse injury, atelectasis, alveolar oedema, the presence of fibrin exudate and hyaline membraneDiffuse injury, atelectasis, alveolar oedema, the presence of fibrin exudate, hyaline membrane and capillary thrombi
Crs—see also figure 1Lung compliance may appear to be normal initially and then decreases over first minutes and hours of life requiring increasing pressures/ventilatory supportPatients initially present with near-normal lung compliance and then have decreasing lung compliance over the next days of illness if the disease progress
SteroidsUse of antenatal steroids reduces RDS7Use of dexamethasone in patients hospitalised with respiratory failure improves outcome20
  • ARDS, acute respiratory distress syndrome; Crs, compliance of the respiratory system; RDS, respiratory distress syndrome.