Beta | HR (95% CI for HR) | Likelihood ratio test | Likelihood ratio test P value | P value PH assumption (<0.05 indicates violation) | |
Univariate Cox PH analysis on all patients (n=32): setting A | |||||
Gender male vs female | 1.20 | 3.3 (0.71 to 15) | 3.00 | 0.08 | 0.52 |
Monocytes (×109/L) | 3.10 | 23 (1.6 to 340) | 4.80 | 0.03* | 0.26 |
Monocytes (>0.9×109/L) | 1.40 | 3.9 (1.3 to 12) | 4.90 | 0.03* | 0.40 |
Monocytes (median) | 1.30 | 3.8 (1.2 to 13) | 5.70 | 0.02* | 0.70 |
Lymphocytes (×109/L) | 0.47 | 1.6 (0.64 to 4) | 0.98 | 0.32 | 0.05 |
Lymphocytes (<1.0×109/L) | 0.80 | 2.2 (0.28 to 18) | 0.47 | 0.49 | 0.24 |
Lymphocyte (median) | 0.39 | 1.5 (0.51 to 4.2) | 0.52 | 0.47 | 0.002 |
Neutrophil (×109/L) | 0.57 | 1.8 (1.3 to 2.3) | 18.00 | 2.0×10−5* | 0.29 |
Neutrophil (>7.5×109/L) | 3.80 | 43 (4.2 to 430) | 12.00 | 0.00065* | 0.06 |
Neutrophil (median) | 1.40 | 4.1 (1.3 to 12) | 6.60 | 0.01* | 0.85 |
FVC (%predicted) at initial CT | −0.02 | 0.98 (0.95 to 1) | 3.40 | 0.07 | 0.60 |
Smoking (never vs ex) | −0.43 | 0.65 (0.17 to 2.5) | 0.37 | 0.54 | 0.03 |
Age at initial CT | −0.02 | 0.98 (0.92 to 1) | 0.32 | 0.57 | 0.57 |
Univariate Cox PH models on patients who progressed to IPF in analysis period (n=17): setting B | |||||
Gender male vs female | 0.85 | 2.3 (0.52 to 10) | 1.50 | 0.22 | 0.84 |
Monocytes (×109/L) | 3.50 | 33 (1.8 to 600) | 5.50 | 0.02* | 0.73 |
Monocytes (>0.9×109/L) | 1.10 | 3 (0.95 to 9.7) | 3.20 | 0.07 | 0.67 |
Monocytes (median) | 1.40 | 3.9 (1.2 to 13) | 5.60 | 0.02* | 0.88 |
Lymphocytes (×109/L) | 0.32 | 1.4 (0.49 to 3.8) | 0.37 | 0.55 | 0.002 |
Lymphocytes (<1.0×109/L) | 2.70 | 15 (0.97 to 250) | 3.00 | 0.09 | 0.16 |
Lymphocyte (median) | −0.05 | 0.95 (0.33 to 2.7) | 0.01 | 0.93 | 0.003 |
Neutrophil (×109/L) | 0.43 | 1.5 (1.2 to 2) | 9.70 | 0.002* | 0.44 |
Neutrophil (>7.5×109/L) | 3.00 | 20 (2 to 200) | 7.80 | 0.005* | 0.06 |
Neutrophil (median) | 1.10 | 3.1 (1 to 9.7) | 4.30 | 0.04* | 0.89 |
FVC (% predicted) at initial CT | −0.003 | 1 (0.97 to 1) | 0.06 | 0.81 | 0.61 |
Smoking (never vs ex) | −0.42 | 0.65 (0.17 to 2.5) | 0.36 | 0.55 | 0.08 |
Age at initial CT | 0.03 | 1 (0.96 to 1.1) | 0.66 | 0.42 | 0.60 |
FVC, forced vital capacity; IPF, idiopathic pulmonary fibrosis.