Table 2

Univariate COX proportional hazard analysis of cohort

BetaHR (95% CI for HR)Likelihood ratio testLikelihood ratio test P valueP value PH assumption (<0.05 indicates violation)
Univariate Cox PH analysis on all patients (n=32): setting A
 Gender male vs female1.203.3 (0.71 to 15)3.000.080.52
 Monocytes (×109/L)3.1023 (1.6 to 340)4.800.03*0.26
 Monocytes (>0.9×109/L)1.403.9 (1.3 to 12)4.900.03*0.40
 Monocytes (median)1.303.8 (1.2 to 13)5.700.02*0.70
 Lymphocytes (×109/L)0.471.6 (0.64 to 4)0.980.320.05
 Lymphocytes (<1.0×109/L)0.802.2 (0.28 to 18)0.470.490.24
 Lymphocyte (median)0.391.5 (0.51 to 4.2)0.520.470.002
 Neutrophil (×109/L)0.571.8 (1.3 to 2.3)18.002.0×10−5*0.29
 Neutrophil (>7.5×109/L)3.8043 (4.2 to 430)12.000.00065*0.06
 Neutrophil (median)1.404.1 (1.3 to 12)6.600.01*0.85
 FVC (%predicted) at initial CT−0.020.98 (0.95 to 1)3.400.070.60
 Smoking (never vs ex)−0.430.65 (0.17 to 2.5)0.370.540.03
 Age at initial CT−0.020.98 (0.92 to 1)0.320.570.57
Univariate Cox PH models on patients who progressed to IPF in analysis period (n=17): setting B
 Gender male vs female0.852.3 (0.52 to 10)1.500.220.84
 Monocytes (×109/L)3.5033 (1.8 to 600)5.500.02*0.73
 Monocytes (>0.9×109/L)1.103 (0.95 to 9.7)3.200.070.67
 Monocytes (median)1.403.9 (1.2 to 13)5.600.02*0.88
 Lymphocytes (×109/L)0.321.4 (0.49 to 3.8)0.370.550.002
 Lymphocytes (<1.0×109/L)2.7015 (0.97 to 250)3.000.090.16
 Lymphocyte (median)−0.050.95 (0.33 to 2.7)0.010.930.003
 Neutrophil (×109/L)0.431.5 (1.2 to 2)9.700.002*0.44
 Neutrophil (>7.5×109/L)3.0020 (2 to 200)7.800.005*0.06
 Neutrophil (median)1.103.1 (1 to 9.7)4.300.04*0.89
 FVC (% predicted) at initial CT−0.0031 (0.97 to 1)0.060.810.61
 Smoking (never vs ex)−0.420.65 (0.17 to 2.5)0.360.550.08
 Age at initial CT0.031 (0.96 to 1.1)0.660.420.60
  • FVC, forced vital capacity; IPF, idiopathic pulmonary fibrosis.