Table 1

Characteristics for patients with iUIP who had at least two CT scans (n=32), at the point of initial CT when iUIP was identified

Non-progressive iUIPProgressive iUIPP value or OR95% CI
n923
Male6 (66%)18 (78%)1.80.37 to 8.34
Female3 (33%)5 (22%)0.60.12 to 2.64
Age at first CT showing iUIP (±SD)76.7 (±6.2)72.3 (±8.6)p=0.277
Never smoker3 (33%)3 (14%)0.30.06 to 1.70
Ex-smoker6 (67%)19 (86%)3.20.59 to 15.9
Respiratory comorbidity1 (11%)8 (40%)5.30.61 to 65.6
Cardiac comorbidity6 (66%)17 (85%)1.30.27 to 7.52
Diabetes mellitus4 (44%)3 (15%)0.20.05 to 1.17
TLCO (mmol/min/kPa)5.0 (±0.9)5.3 (±1.7)p=0.983
%TLCO77.8 (±18.1)64.2 (±16.0)p=0.077
FVC (l)2.90 (±0.7)3.24 (±1.1)p=0.728
%FVC102.00 (±21.6)92.6 (±26.9)p=0.285
FEV1 (l)2.33 (±0.7)2.36 (±0.7)p=0.853
%FEV198.4 (±18.8)85.9 (±19.4)p=0.362
CPI score67.7 (±18.3)69.5 (±10.4)p=0.327
  • Data are divided into progressor and non-progressor groups. % in parenthesis is proportion of specified group.

  • Statistical analysis expressed at p value or OR with 95% CI. Lung function parameters refer to those measured within 3 months of first CT scan. CPI as calculated by Wells et al.18

  • CPI, Composite Physiological Index ; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; iUIP, indeterminate for UIP; TLCO, carbon monoxide transfer factor; UIP, usual interstitial pneumonia.