Table 3

Multivariate COX proportional hazard analysis of cohort

BetaHR (95% CI for HR)Wald test p valueP value PH assumption (<0.05 indicates violation)
Multivariate Cox PH analysis on all patients (n=32) (setting A)
 Gender male vs female0.641.90 (0.35 to 10)0.460.92
 Age at initial CT−0.070.93 (0.85 to 1)0.150.84
 Smoking (never vs ex)−2.300.10 (0.015 to 0.72)0.02*0.09
 FVC (% predicted) at initial CT−0.040.96 (0.92 to 1)0.05*0.71
 Monocytes (>0.9×109 /L)3.3027 (2 to 370)0.01*0.09
 Lymphocytes (<1.0×109 /L)−1.000.37 (0.013 to 10)0.560.85
 Neutrophil (>7.5×109 /L)3.5035 (1.7 to 680)0.02*0.06
GLOBAL significance=likelihood ratio test 21 (p=0.004), PH assumption p=0.18
Multivariate Cox PH models on patients who progressed to IPF in analysis period (n=17) (setting B)
 Gender male vs female1.303.50 (0.52 to 24)0.200.43
 Age at initial CT−0.140.87 (0.78 to 0.97)0.02*0.20
 Smoking (never vs ex)−3.400.03 (0.0028 to 0.42)0.008*0.37
 FVC (% predicted) at initial CT−0.050.95 (0.89 to 1)0.070.23
 Monocytes (>0.9×109/L)8.806700 (19 to 2400000)0.003*0.87
 Lymphocytes (<1.0×109/L)−5.000.01 (4.7−5 to 1)0.050.34
 Neutrophil (>7.5×109/L)5.20180 (2.3 to 14000)0.02*0.24
GLOBAL significance=likelihood ratio test 21 (p=0.004), PH assumption p=0.69.
  • GLOBAL significance=likelihood ratio test 21 (p=0.004), PH assumption p=0.69.

  • FVC, forced vital capacity.