Demographics by genotype group*
| Overall (0 to <12 years of age) | 0 to <2 years of age | 2 to <6 years of age | 6 to <12 years of age | |
| Overall, n† | 9185 | 1593 | 2979 | 4613 |
| Age, mean (SD) | 6.0 (3.5) | 1.0 (0.6) | 4.0 (1.2) | 9.1 (1.7) |
| Female, n (%) | 4586 (49.9) | 773 (48.5) | 1456 (48.9) | 2357 (51.1) |
| White, n (%) | 8505 (92.6) | 1449 (91.0) | 2726 (91.5) | 4330 (93.9) |
| F508del/F508del, n† | 4398 | 708 | 1382 | 2308 |
| Age, mean (SD) | 6.2 (3.5) | 1.0 (0.6) | 4.0 (1.2) | 9.1 (1.7) |
| Female, n (%) | 2183 (49.6) | 339 (47.9) | 682 (49.3) | 1162 (50.3) |
| White, n (%) | 4242 (96.5) | 680 (96.0) | 1324 (95.8) | 2238 (97.0) |
| F508del/MF, n† | 1887 | 304 | 586 | 997 |
| Age, mean (SD) | 6.2 (3.5) | 1.0 (0.6) | 4.0 (1.1) | 9.0 (1.7) |
| Female, n (%) | 972 (51.5) | 156 (51.3) | 299 (51.0) | 517 (51.9) |
| White, n (%) | 1739 (92.2) | 277 (91.1) | 537 (91.6) | 925 (92.8) |
| Gating mutation on ≥1 allele, n† | 439 | 82 | 137 | 220 |
| Age, mean (SD) | 6.0 (3.6) | 1.0 (0.5) | 4.0 (1.1) | 9.1 (1.7) |
| Female, n (%) | 220 (50.1) | 35 (42.7) | 64 (46.7) | 121 (55.0) |
| White, n (%) | 410 (93.4) | 76 (92.7) | 127 (92.7) | 207 (94.1) |
| RF on ≥1 allele, n† | 438 | 113 | 151 | 174 |
| Age, mean (SD) | 5.0 (3.4) | 1.1 (0.5) | 3.7 (1.1) | 8.7 (1.8) |
| Female, n (%) | 216 (49.3) | 59 (52.2) | 70 (46.4) | 87 (50.0) |
| White, n (%) | 400 (91.3) | 102 (90.3) | 136 (90.1) | 162 (93.1) |
| MF/MF, n†‡ | 336 | 51 | 116 | 169 |
| Age, mean (SD) | 6.2 (3.5) | 1.0 (0.6) | 4.0 (1.1) | 9.2 (1.7) |
| Female, n (%) | 175 (52.1) | 25 (49.0) | 53 (45.7) | 97 (57.4) |
| White, n (%) | 267 (79.5) | 38 (74.5) | 96 (82.8) | 133 (78.7) |
| R117H on ≥1 allele, n† | 262 | 52 | 109 | 101 |
| Age, mean (SD) | 5.2 (3.4) | 1.0 (0.6) | 3.8 (1.1) | 8.9 (1.7) |
| Female, n (%) | 120 (45.8) | 25 (48.1) | 41 (37.6) | 54 (53.5) |
| White, n (%) | 255 (97.3) | 49 (94.2) | 105 (96.3) | 101 (100) |
*The genotype groups displayed are not exhaustive; therefore, subgroups do not sum to 9185.
†n indicates the number of children with non-missing data.
‡Online supplemental table S1 provides a full list of qualifying MF mutations.
MF, minimal function; RF, residual function.