Table 3

Association between baseline characteristics and changes in D-12 questionnaire scores at short term (M2)

Baseline	D-12 Physical ΔM2 - baseline		D-12 Affective ΔM2 - baseline		D-12 Total ΔM2 - baseline
Baseline	Estimates±SE	P value	Estimates±SE	P value	Estimates±SE	P value
Age, 1 year increase	0.01±0.03	0.67	0.03±0.02	0.22	0.04±0.05	0.40
Sex, female versus male	0.83±0.74	0.26	−0.07±0.56	0.90	0.79±1.19	0.51
BMI,1 kg/m² increase	−0.12±0.04	<0.01	−0.07±0.03	0.03	−0.19±0.06	<0.01
FEV₁, 1% of predicted value increase	−0.07±0.02	<0.01	−0.06±0.02	<0.001	−0.13±0.04	<0.001
Charlson Index, 1-point increase	−0.03±0.12	0.78	0.11±0.10	0.29	0.15±0.20	0.46
VSRQ, 1-point increase	−0.04±0.03	0.26	−0.06±0.03	0.03	−0.10±0.05	0.07
Anxiety symptom, score >11	0.74±0.76	0.33	2.07±0.63	0.001	2.46±1.28	0.056
Depression symptom, score >11	0.04±0.84	0.97	0.96±0.66	0.14	0.86±1.38	0.53
FAS, 1 log in total score increase	−1.15±1.13	0.31	1.39±0.85	0.10	2.57±1.88	0.17
6MST, 1 stroke increase	−0.003±0.003	0.31	−0.005±0.002	0.01	−0.008±0.004	0.08

Results of the parametric analysis of covariance, adjusted for baseline value. mMRC scales were not included in the analysis due to the collinearity with D-12 questionnaire.
BMI, body mass index; D-12, Dyspnoea-12; FAS, Fatigue Assessment Scale; FEV₁, forced expiratory volume in 1 s; mMRC, modified Medical Research Council; 6MST, 6 min stepper test; VSRQ, Visual Simplified Respiratory Questionnaire.