Changes in L-PF Dyspnoea and Cough scores across strata of 52-week change in FVC % predicted strata
| Change in FVC % predicted† | F-statistic‡ | Pairwise comparisons§ | ||||||||||||||
| Large deterioration | Moderate deterioration | Minimal deterioration | Stable | Minimal improvement | Moderate improvement | Large improvement | ||||||||||
| N | Mean (SD) change from baseline | N | Mean (SD) change from baseline | N | Mean (SD) change from baseline | N | Mean (SD) change from baseline | N | Mean (SD) change from baseline | N | Mean (SD) change from baseline | N | Mean (SD) change from baseline | |||
| L-PF Dyspnoea score | 170 | 13.4 (17.2) | 103 | 4.8 (15.5) | 67 | 1.1 (12.9) | 96 | 1.0 (13.7) | 36 | 0.8 (9.0) | 33 | −4.0 (8.6) | 25 | −0.9 (14.4) | 14.4*** | 1**, 2***, 3***, 4**, 5***, 6** |
| L-PF Cough score | 168 | 8.8 (23.3) | 102 | 0.2 (21.8) | 67 | −3.2 (20.1) | 95 | −2.3 (24.7) | 36 | −5.4 (30.4) | 32 | −6.5 (20.5) | 26 | −16.7 (20.5) | 7.4*** | 2*, 3*, 6*** |
L-PF Symptoms scores range from 0 to 100, with higher scores indicating greater impairment.
**P<0.05, **p<0.01, ***p<0.001.
†Large deterioration: decline >10% predicted; moderate deterioration: decline >5% and ≤10% predicted; minimal deterioration: decline >2% and ≤5% predicted; stable: decline ≤2% predicted or increase ≤2% predicted; minimal improvement: increase >2% and ≤5% predicted; moderate improvement: increase >5 and ≤10% predicted; large improvement: increase >10% predicted.
‡One-way analyses of variance (generalised linear model) overall F-statistic.
§Pairwise comparisons using Scheffe’s method: 1=large deterioration versus moderate deterioration, 2=large deterioration versus minimal deterioration, 3=large deterioration versus stable, 4=large deterioration versus minimal improvement, 5=large deterioration versus moderate improvement, 6=large deterioration versus large improvement, 7=moderate deterioration versus minimal deterioration, 8=moderate deterioration versus stable, 9=moderate deterioration versus minimal improvement, 10=moderate deterioration versus moderate improvement, 11=moderate deterioration versus large improvement, 12=minimal deterioration versus stable, 13=minimal deterioration versus minimal improvement, 14=minimal deterioration versus moderate improvement, 15=minimal deterioration versus large improvement, 16=stable deterioration versus minimal improvement, 17=stable deterioration versus moderate improvement, 18=stable deterioration versus large improvement, 19=minimal improvement versus moderate improvement, 20=minimal improvement versus large improvement and 21=moderate improvement versus large improvement.
FVC, forced vital capacity; L-PF, Living with Pulmonary Fibrosis.